A synthetic analog of growth hormone-releasing hormone (GHRH 1-29) previously FDA-approved for diagnosing and treating growth hormone deficiency in children.
Pancreas|1988|Robberecht P et al.
Crude membranes (27,000 g pellets) from five normal human pancreases were prepared. In the presence of GTP, the peptides of the secretin family stimulated adenylate cyclase activity, their order of potency being: secretin greater than helodermin grea…
PMID: 3186683
Endokrynologia Polska|1988|Krzyzagórska E, Kosowicz J
The studies aimed at evaluation of pituitary reserve of growth hormone following stimulation with GRF have been carried out in a group of 33 patients (11 women and 22 men, of age between 25 and 62 years) with pituitary tumors. The studied material in…
PMID: 3151885
Reproduction, nutrition, developpement|1988|Sauvant D et al.
Daily injections of GRF 1-29 significantly increased milk production of goats. Effects of injections were slightly positive on voluntary intake and negative on energy balance.
PMID: 3151137
Domestic animal endocrinology|1988|Grings E et al.
Sixteen pregnant Holstein heifers (430kg) were used to determine the effect of long-term administration of a bovine growth hormone (bGH) made by recombinant DNA technology on the ability of a bolus injection of a growth hormone-releasing hormone anal…
PMID: 3147164
Clinical endocrinology|1988|Kopelman P et al.
Increased plasma concentrations of growth hormone (GH) are reported in diabetes and it is suggested that this may be important in the development of complications. We have investigated fasting GH levels and the response to 100 micrograms i.v. growth…
PMID: 3139333
Reproduction, nutrition, developpement|1988|Pastoureau P et al.
Injections of hGRF rapidly stimulated GH secretion in lamb and this response was significantly higher in hypotrophic than in normal lambs. The treatment had an effect on body composition reducing the retention of lipids and the energy level and incre…
PMID: 3131856
Neuroendocrinology|1988|Casanueva F et al.
In humans, corticoids suppress growth hormone (GH) secretion elicited by a variety of stimuli, while in vitro they potentiate GH release. To further study this problem, the effect of two doses of dexamethasone on GH secretion elicited by GH-releasing…
In Vitro
PMID: 3124015
Hormone research|1988|Hernández M et al.
In the present study we report the effects of therapy with growth hormone-releasing factor (1-29)NH2 (GRF) on growth rate, plasma levels of insulin growth factor I (IGF-I) and growth hormone (GH) secretion in 11 children who were selected solely on t…
PMID: 2907992
Acta pharmaceutica Suecica|1988|Lodén M, Faijerson Y
PMID: 2901184
Journal of dairy science|1988|Lapierre H et al.
Twelve cows (209 d in lactation, 642 kg BW) were used in an experiment conducted over four 10-d periods (one preinjection, one injection, and two postinjection). Gelatine (n = 6) or 10 mg of growth hormone-releasing factor in gelatine (n = 6) was inj…
PMID: 2897385
International journal of peptide and protein research|1988|Fournier A, Wang C, Felix A
The BOP reagent [benzotriazol-l-yl-oxy-tris-(dimethylamino)phosphonium hexa-fluorophosphate] introduced by Castro et al. [Tetrahedron Lett. (1975) 14, 1219-1222] is ideally suited for solid phase peptide synthesis. The rate of coupling using BOP comp…
PMID: 2896637
Peptides|1988|Rafferty B, Coy D, Poole S
D-amino acid-substituted analogues of growth hormone-releasing factor 1-29)-amide with superagonist activities in the rat were examined for increased plasma half-life and resistance to degradation in vivo. After IV injection, half-lives of the analog…
Animal Study
PMID: 2896343
Life sciences|1988|Kovacs M et al.
The effects of new Agmatine (Agm) analogs of human growth hormone-releasing hormone (GH-RH) were compared to GH-RH (1-29)NH2 and to (D-Ala2)GH-RH(1-29)NH2 after intravenous (IV) and subcutaneous (SC) administration to pentobarbital-anesthetised male…
Animal StudyIn Vitro
PMID: 2892105
British journal of haematology|1987|Leiper A et al.
Seventeen children (11 M, 6 F) with acute leukaemia and myeloproliferative disorders were investigated for growth and endocrine dysfunction. All had undergone bone marrow transplantation prepared with cyclophosphamide and single fraction total body i…
PMID: 3322361
Clinical endocrinology|1987|Ross R et al.
We have studied the effect of increased cholinergic tone on the GH response to growth hormone-releasing hormone (GHRH) and on GH feedback, using pyridostigmine, an acetylcholinesterase inhibitor. In six healthy male adult volunteers 120 mg oral pyrid…
Clinical Trial
PMID: 2901302
Journal of dairy science|1987|Pelletier G et al.
Eighteen multiparous Holstein cows in the second half of their lactation were used to determine the effect of human growth hormone-releasing factor (1-44)NH2 and a fragment of growth hormone-releasing factor (1-29)NH2 on lactational performance and f…
PMID: 2896206
Acta endocrinologica|1987|Ranke M et al.
In a total of 56 children and adolescents with Turner's syndrome (41 with karyotype 45,X) basal serum levels of somatomedin bioactivity, Sm-C/IGF-I (RIA), IGF II (RIA), GH response to arginine and GHRH (GRF(1-29)NH2), and spontaneous GH secretion dur…
PMID: 3687318
Clinical endocrinology|1987|Casanueva F et al.
Anorexia nervosa is associated with several abnormalities in GH secretion elicited by different stimuli. To investigate the precise mechanism of this alteration, GHRH was administered to 14 women: a group of eight anorexia nervosa patients in the acu…
Randomized Controlled Trial
PMID: 2897260
Domestic animal endocrinology|1987|Dubreuil P et al.
The aim of this study was to determine the effect of age and sex on basal secretory patterns of growth hormone (GH) and growth hormone-releasing factor (GRF) induced GH release. Eighteen pigs (9 castrated males and 9 females) were stimulated with pGR…
Animal Study
PMID: 2907313
Domestic animal endocrinology|1987|Lapierre H et al.
Sixteen male Holstein calves averaging 168 kg body weight (BW) were used to determine the effects of human growth hormone-releasing factor (1-29)NH2 (hGRF (1-29)NH2; .22 micrograms/kg BW), thyrotropin-releasing factor (TRF; .165 micrograms/kg BW) or…
PMID: 2907311