[Effects of GRF 1-29 in normal and hypotrophic lambs].

Reproduction, nutrition, developpement1988PMID: 3131856

Plain Language Summary

Injections of sermorelin (GRF 1-29) stimulated growth hormone secretion in lambs, with undersized (hypotrophic) lambs showing a significantly greater response than normal lambs. The treatment altered body composition by reducing fat retention and boosting calcium and phosphorus content, indicating that sermorelin promotes both metabolic changes and skeletal growth in young ruminants.

Abstract

Injections of hGRF rapidly stimulated GH secretion in lamb and this response was significantly higher in hypotrophic than in normal lambs. The treatment had an effect on body composition reducing the retention of lipids and the energy level and increasing calcium and phosphorus content. The results showed that GRF affected both metabolism and skeletal growth of ruminants, stimulating specially the production of Sm-C and proliferation of chondrocytes.

Authors

Pastoureau, P; Barenton, B; Blanchard, M; Boivin, G; Charrier, J; Dulor, J P; Theriez, M