Studies

Fanconi anaemia (FA) is a DNA-repair disorder that compresses multiple hallmarks of ageing into childhood and early adulthood. Persistent genomic instability in FA precipitates oxidative stress, inflammatory remodelling, and metabolic reprogramming,…

BACKGROUND: Avascular necrosis (AVN) of the femoral head is a progressive condition that leads to collapse of the femoral head in 85% of symptomatic patients when left untreated. As it is typically a disease that occurs among the younger population,…

Newborn screening (NBS) is a cost-effective public health strategy for the early detection of congenital disorders that cause neonatal/infant morbidity and mortality. It is standard care in many high-income and emerging economies. Nigeria, despite it…

Obesity affects over 2 billion adults globally, with projections indicating that nearly two-thirds of adults will be affected by 2050. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have transformed obesity treatment, achieving weight loss prev…

1. This study investigated whether resveratrol (RES) can regulate the expression of duck cathelicidins (dCATHs) in heterophilic granulocytes (HGs). To address this, HG was isolated from ducks and treated with RES, followed by transcriptome sequencing…

PURPOSE: This study aimed to examine the acute effects of continuous and interval cycling on salivary secretory immunoglobulin A (SIgA) and anti-microbial peptides. METHODS: In a randomized crossover trial, 12 healthy young untrained men (22 ± 1 year…

Rosacea is a chronic inflammatory disease of facial skin with unknown pathophysiology. Abnormal overexpression of human antimicrobial peptide LL-37 is a hallmark of rosacea. However, its significance in rosacea pathogenesis is not fully understood. W…

Rosacea is a chronic inflammatory skin condition marked by excessive M1 macrophage polarization and angiogenesis, resulting in erythema and tissue inflammation. Despite available treatments, many patients experience recurrent flare-ups. This study ex…

Dysregulation of low-density lipoprotein (LDL) cholesterol is strongly correlated with the risk of metabolic dysfunction-associated steatotic liver disease. Endogenous molecules targeting LDL clearance play crucial roles in the progression of liver s…

Lipid droplets (LDs) are lipid-rich organelles recognized as central players in lipid homeostasis, signaling, and inflammation. While their functions in inflammation are well-documented, the mechanisms of LDs in antibacterial immunity and infection r…

Due to the complex and variable microenvironment of wounds, bleeding and persistent infections have always posed significant challenges in wound treatment. Designing and developing therapeutic solutions with rapid hemostatic capabilities and antibact…

BACKGROUND: Respiratory, gastrointestinal, and allergic diseases can significantly affect children's physical and mental health and quality of life. PURPOSE: This study aimed to assess the safety of Bifidobacterium animalis subsp. lactis BLa80, its p…

GF-17, the main antimicrobial domain of LL-37, exhibits optimal amphipathicity and heightened hydrophobicity, leading to increased hemolytic activity. A series of novel GF-17-like antimicrobial peptides (AMPs) were designed using lysine scanning to e…

Bacterial extracellular vesicles (BEVs) serve as efficient drug-delivery vehicles for bioactive molecules including antimicrobial peptides (AMPs). In the present study, human cathelicidin-derived AMP LL37 was encapsulated in Streptococcus parauberis-…

Owing to emerging global threats such as viral pandemics and the rise of antibiotic resistance, there is an urgent need for novel approaches to combat drug-resistant pathogens. Antimicrobial peptides (AMPs), also known as cationic host defense peptid…

Viral infectious diseases rank among the leading causes of mortality globally. The rise of drug resistance mechanisms puts the effectiveness of all existing antimicrobial drugs at risk, several of which have become ineffective. Consequently, there is…

The terpenoid compounds geosmin (GSM) and 2-methylisoborneol (MIB), produced by a wide range of microorganisms, are abundant in many aquatic environments. Both compounds are easily detectable by humans (<5 ng/L), and they are often associated with an…

The rise of antimicrobial resistance (AMR) has outpaced the development of new antibiotics, necessitating alternative therapeutic strategies that do not rely on conventional bactericidal approaches. Quorum-sensing (QS), a bacterial communication syst…