The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
This study aimed to determine the serum levels of the LL-37 molecule, associated with the pathophysiology of Brucellosis, in patients diagnosed with Brucellosis and to investigate the relationship between these levels and the clinical course of the d…
Macrophage antimicrobial programs are regulated not only by transcriptional networks but also by RNA processing mechanisms affecting signal transduction and effector responses. One such mechanism, alternative polyadenylation (APA), determines mRNA fa…
Multidrug-resistant Gram-negative pathogens pose a major global medical challenge due to the lack of new antibiotics. Outer membrane vesicles (OMVs) in Gram-negative bacteria significantly contribute to their resistance to antimicrobial peptides (AMP…
UNLABELLED: Atherosclerosis is the common underlying pathology in atherosclerotic cardiovascular disease (ASCVD) phenotypes of myocardial infarction (MI), stroke or peripheral artery disease (PAD). Single immune cell profiling of atherosclerotic plaq…
1. This study investigated whether resveratrol (RES) can regulate the expression of duck cathelicidins (dCATHs) in heterophilic granulocytes (HGs). To address this, HG was isolated from ducks and treated with RES, followed by transcriptome sequencing…
BACKGROUND: ApoB (apolipoprotein B)-containing lipoproteins are causal risk factors for atherosclerotic coronary artery disease (CAD). Since human cathelicidin LL-37 binds to ApoB-100 in this pathological context, we investigated whether the circulat…
Human mesenchymal stem cells (hMSCs) are versatile cells obtained from various regions of the human body. Beyond their potential for cell replacement, MSCs secrete a wide range of growth factors and cytokines and have recently been recognized for the…
The limited selectivity of antimicrobial peptides (AMPs) can lead to unintended damage to healthy eukaryotic cells, a process strongly influenced by membrane physicochemical properties. Cholesterol (CHO) is a key regulator of lipid packing, membrane…
INTRODUCTION: Periodontitis is a plaque-induced condition that causes irreparable damage to the supporting tissues of the teeth, and tobacco smoking is a recognized exacerbating and risk factor. Antibiotic-resistant bacteria are a consequence of anti…
The pathogenicity of Group A Streptococcus (GAS) is tightly regulated by the CovRS two-component system; however, the nature of the direct interaction between CovR and CovS, and how host signals modulate this system, remain poorly understood. Using s…
Antimicrobial peptides (AMPs) are tiny proteins essential for innate immunity in various taxa, including mammals and insects. They provide defence against a wide range of pathogens, including bacteria, viruses, fungi, and parasites. Apart from their…
() is a leading cause of human gastroenteritis worldwide and must overcome intestinal innate immunity, including antimicrobial peptide LL-37. However, howresponds to LL-37 remains unclear. Here, we showed thatinfection stimulates intestinal epithelia…
The increasing resistance and the pathogen's complex multi-drug resistance mechanisms made the selection of effective antimicrobial treatments more challenging for(). The study aimed to explore the effect of,and antimicrobial peptide LL-37 on the vir…
AIMS: This study examines the in vitro antibacterial activity of palatal adipose tissue-derived mesenchymal stem cells (PAT-MSCs) and the expression of antimicrobial peptide LL-37, with a particular focus on the effect of three-dimensional (3D) nanof…
Bacterial keratitis is a potentially blinding corneal infection, withandbeing the leading gram-positive and gram-negative pathogens, respectively. The increasing antimicrobial resistance among these pathogens necessitates the development of newer the…
INTRODUCTION: Urinary catheterization frequently causes urinary tract infections and patient discomfort. While hydrogel coatings combining antibacterial and hydrophilic properties offer a potential solution, challenges such as uncontrolled antimicrob…
Mesenchymal stem cells (MSCs) have emerged as promising alternatives to fight drug-resistant bacterial infections. This study investigates the antibacterial activity of palatal adipose tissue-derived MSCs (PMSCs), particularly when cultured within a…
BACKGROUND: Pneumonia remains a leading cause of morbidity and mortality among children globally, especially in low- and middle-income countries, where poor nutrition and limited access to healthcare increase vulnerability. Vitamin D deficiency is co…
Human cathelicidin peptide LL-37 is encoded by the CAMP gene and plays a key role in innate immunity. It maintains intestinal homeostasis through antibacterial, immunomodulation, and tissue repair functions. This paper reviews the multiple functions…