The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
The escalating global threat of antimicrobial resistance (AMR) and chronic biofilm-associated infections underscores the urgent need for novel therapeutic agents. Antimicrobial peptides (AMPs) offer a promising alternative due to their potent activit…
Effective management of infected skin wounds remains a major clinical challenge, particularly as rising antibiotic resistance compromises conventional therapies. Antimicrobial peptides (AMPs) have emerged as promising alternatives, but their clinical…
Quercetin-loaded cellulose nanocrystals (QL-CNC) were developed as a reactive oxygen species (ROS)-responsive nanocarrier for the targeted treatment of rosacea. A murine model of rosacea-like dermatitis was induced using LL-37. The therapeutic effica…
Malaria control is challenged by the emergence of resistance to virtually all antimalarial drugs, from the frontline artemisinin to other classes, highlighting the critical need for new therapies. This study demonstrates that the human antimicrobial…
Sterile inflammation, resulting from hepatocyte death and subsequent release of damage-associated molecular patterns (DAMPs), significantly contributes to liver disease pathogenesis. Neutrophils, as primary responders to liver injury, undergo NETosis…
Chronic diabetic wounds do not heal and are often accompanied by infections and poor angiogenesis. We have made a two-layered PVA/CS composite hydrogel MN-CL patch, which has antibacterial, immunoregulatory, and pro-healing properties. The needle tip…
: Bacterial biofilms formed bypose a significant challenge in veterinary medicine due to their intrinsic resistance to antibiotics. Antimicrobial peptides (AMPs) represent a promising alternative. AMPs exert their bactericidal activity by binding to…
Host defense peptides (HDPs), ancestral effectors of innate immunity, have emerged as pleiotropic regulators transcending their antimicrobial origins. This review critically examines the complex interplay among HDPs, hemostasis, and tissue repair. We…
The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection-caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation,…
Dysregulation of low-density lipoprotein (LDL) cholesterol is strongly correlated with the risk of metabolic dysfunction-associated steatotic liver disease. Endogenous molecules targeting LDL clearance play crucial roles in the progression of liver s…
BACKGROUND AND AIMS: Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause small intestinal injury and dysbiosis. Although NSAID-induced dysbiosis is well-characterized and contributes to enteropathy, the changes in host-bacterial interactions duri…
INTRODUCTION: Rosacea is a persistent inflammatory dermatosis with a multifactorial etiology that significantly impairs patients' daily life and wellbeing. Vicenin-2, a natural flavonoid, has shown anti-inflammatory potential; however, its therapeuti…
OBJECTIVE: This study aimed to elucidate the molecular mechanisms through which CXCL2 contributes to the pathogenesis of idiopathic interstitial pneumonia (IIP). METHODS: Neutrophils were isolated, and the formation of neutrophil extracellular traps…
Periapical periodontitis (AP) is an inflammatory disease caused by persistent endodontic biofilms, and its treatment remains challenging because conventional root canal therapy sometimes fails to achieve effective disinfection and tissue regeneration…
Klebsiella pneumoniae is one of the major pathogens responsible for multiple infections in clinical settings，and especially, the emergence of highly pathogenic variant known as hypervirulent K. pneumoniae (hvKp) poses an increasing threat to public h…
The double cooperative effect between two major antimicrobial peptides, LL-37 and HNP1, where their combination enhances antimicrobial efficiency while reducing cytotoxicity, offers a promising strategy for developing safer and more effective antibio…
Dynamic changes in lipid membrane composition are a common response to stress, often involving shifts in key lipid molecules. Phosphatidic acid (PA), a central precursor in lipid biosynthesis, accumulates when anionic phospholipid synthesis is blocke…
Viral infectious diseases rank among the leading causes of mortality globally. The rise of drug resistance mechanisms puts the effectiveness of all existing antimicrobial drugs at risk, several of which have become ineffective. Consequently, there is…
The fever response is triggered during infection and inflammation, but the importance of this response for the function of antimicrobial peptides (AMPs) remains unknown. We discovered that the activity of the human AMP LL-37 is temperature-dependent…