The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
Urinary proteins offer multifaceted insights into tissue repair, dysfunction, and renal health, with significant implications for both human and veterinary medicine. However, marine mammal medicine lacks comprehensive studies on urine protein composi…
Antimicrobial resistance (AMR) undermines the effectiveness of antibiotic treatment, and due to this, it now worldwide health concern. In general, antibiotics are used to control or combat bacteria, their widespread and irresponsible has contributed…
BACKGROUND: The evidence of a low-biomass microbial community in the amniotic fluid (AF) is challenging the traditional concept of a sterile womb. To clarify microbial presence and host responses, a comprehensive, multi-methodological approach is req…
BACKGROUND: During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolve…
INTRODUCTION: Rosacea is a persistent inflammatory dermatosis with a multifactorial etiology that significantly impairs patients' daily life and wellbeing. Vicenin-2, a natural flavonoid, has shown anti-inflammatory potential; however, its therapeuti…
OBJECTIVES: The increasing prevalence of antibiotic-resistant Salmonella Typhimurium has highlighted the urgent need for alternative therapeutic strategies. This study engineered a lytic S. Typhimurium bacteriophage to present the antimicrobial pepti…
Protamine is a polybasic drug commonly used in cardiac surgery to chemically inhibit, and thereby reverse, the anticoagulant effect of heparin. However, protamine can trigger severe anaphylaxis, with both IgE-dependent and IgE-independent mechanisms…
BACKGROUND: Dental plaque is a highly organized polymicrobial biofilm, in which extracellular DNA serves as a vital structural and functional component of the extracellular matrix. The human antimicrobial peptide LL-37 plays an important role in oral…
BACKGROUND: The growing threat of bacterial drug resistance compels researchers to pursue new therapeutic strategies. Finegoldia magna secretes SufA, a subtilisin- like protease that plays a critical role in virulence by degrading host defense molecu…
Klebsiella pneumoniae is one of the major pathogens responsible for multiple infections in clinical settings，and especially, the emergence of highly pathogenic variant known as hypervirulent K. pneumoniae (hvKp) poses an increasing threat to public h…
The increasing prevalence of multidrug-resistant (MDR) bacterial infections poses global health challenges, highlighting the urgent need for new antimicrobial agents. The key advantages of antimicrobial peptides are their ability to rapid bactericida…
Mastitis is a major cause of economic losses in dairy production; however, its prevention and treatment remain challenging. Under field conditions, antimicrobial drugs are frequently administered when somatic cell counts (SCCs) are elevated and signs…
BACKGROUND: Visceral fat (VF), particularly epicardial adipose tissue (EAT), plays a crucial role in the development of coronary artery disease (CAD). Cathelicidin (LL37) is an antimicrobial peptide involved in innate immunity and has been implicated…
BACKGROUND: During the COVID-19 pandemic, it became evident that an infection with SARS-CoV-2 is associated with an increased predisposition for thrombembolic events. Recent studies suggest an excessive neutrophil extracellular trap (NET)-formation i…
Non-typeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that causes several respiratory diseases. It employs the Sap (sensitivity to antimicrobial peptide) transporter to achieve resistance against the human antimicrobial peptides (hA…
Effective management of infected skin wounds remains a major clinical challenge, particularly as rising antibiotic resistance compromises conventional therapies. Antimicrobial peptides (AMPs) have emerged as promising alternatives, but their clinical…
Urinary tract infections (UTIs) are the most common bacterial infections in women. During UTI, the host mounts a rapid immune response to clear the invading pathogen. Mast cells are tissue resident immune cells found in the bladder lamina propria and…
Rosacea is a chronic inflammatory skin condition marked by excessive M1 macrophage polarization and angiogenesis, resulting in erythema and tissue inflammation. Despite available treatments, many patients experience recurrent flare-ups. This study ex…