The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
Antimicrobial peptides (AMPs) are tiny proteins essential for innate immunity in various taxa, including mammals and insects. They provide defence against a wide range of pathogens, including bacteria, viruses, fungi, and parasites. Apart from their…
BACKGROUND: The evidence of a low-biomass microbial community in the amniotic fluid (AF) is challenging the traditional concept of a sterile womb. To clarify microbial presence and host responses, a comprehensive, multi-methodological approach is req…
BACKGROUND: ApoB (apolipoprotein B)-containing lipoproteins are causal risk factors for atherosclerotic coronary artery disease (CAD). Since human cathelicidin LL-37 binds to ApoB-100 in this pathological context, we investigated whether the circulat…
Transient receptor potential vanilloid 4 (TRPV4) is a polymodal cation channel that is widely expressed in sensory neurons, immune cells, and structural tissues, where it integrates mechanical, osmotic, and chemical stimuli to regulate both physiolog…
BACKGROUND: The expression of transient receptor potential vanilloid (TRPV) and Toll-like receptor 2 (TLR2) in the lesion sites of patients with rosacea is increased. Ultraviolet B (UVB) radiation can induce inflammation of keratinocytes in patients…
Cathelicidins, a diverse family of host defence peptides (HDPs) in vertebrates, are recognized for their potential in combating resistant microorganisms and their varied biological functions. While extensive studies have focused on mammalian cathelic…
BACKGROUND: Although caries is known to be influenced by diet and oral hygiene factors, susceptibility to the disease may be reduced by host factors, such as saliva antimicrobial peptides (AMPs). However, the relationship between salivary AMPs and ea…
BACKGROUND: Pneumonia remains a leading cause of morbidity and mortality among children globally, especially in low- and middle-income countries, where poor nutrition and limited access to healthcare increase vulnerability. Vitamin D deficiency is co…
INTRODUCTION: Urinary catheterization frequently causes urinary tract infections and patient discomfort. While hydrogel coatings combining antibacterial and hydrophilic properties offer a potential solution, challenges such as uncontrolled antimicrob…
Antimicrobial resistance demands therapeutics that combine potent activity with low resistance potential. Ultrashort antimicrobial peptides (AMPs) are attractive due to their manufacturability and tunability, but activity is often lost upon sequence…
Bacterial keratitis is a potentially blinding corneal infection, withandbeing the leading gram-positive and gram-negative pathogens, respectively. The increasing antimicrobial resistance among these pathogens necessitates the development of newer the…
Macrophage antimicrobial programs are regulated not only by transcriptional networks but also by RNA processing mechanisms affecting signal transduction and effector responses. One such mechanism, alternative polyadenylation (APA), determines mRNA fa…
BACKGROUND: The growing threat of bacterial drug resistance compels researchers to pursue new therapeutic strategies. Finegoldia magna secretes SufA, a subtilisin- like protease that plays a critical role in virulence by degrading host defense molecu…
Klebsiella pneumoniae is one of the major pathogens responsible for multiple infections in clinical settings，and especially, the emergence of highly pathogenic variant known as hypervirulent K. pneumoniae (hvKp) poses an increasing threat to public h…
Mastitis is a major cause of economic losses in dairy production; however, its prevention and treatment remain challenging. Under field conditions, antimicrobial drugs are frequently administered when somatic cell counts (SCCs) are elevated and signs…
Human cathelicidin peptide LL-37 is encoded by the CAMP gene and plays a key role in innate immunity. It maintains intestinal homeostasis through antibacterial, immunomodulation, and tissue repair functions. This paper reviews the multiple functions…
BACKGROUND: Fluorescence photobiomodulation (FPB) is a treatment for canine dermatitis, yet no studies exist assessing its effect on canine keratinocytes in vitro. OBJECTIVES: To determine: (i) the anti-inflammatory and antimicrobial effect of FPB on…
Cross-α amyloids are an emerging class of functional peptide assemblies that underlie biofilm formation and antibiotic resistance in bacteria. Beyond their biological significance, synthetic cross-α architectures exhibit remarkable rigidity and piezo…