The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
Cathelicidins are crucial antimicrobial peptides (AMPs) that play a key role in the innate immunity of marine vertebrates. The pygmy sperm whale (Kogia breviceps), which resides in environments populated by diverse microbial communities, faces comple…
Effective management of infected skin wounds remains a major clinical challenge, particularly as rising antibiotic resistance compromises conventional therapies. Antimicrobial peptides (AMPs) have emerged as promising alternatives, but their clinical…
Human mesenchymal stem cells (hMSCs) are versatile cells obtained from various regions of the human body. Beyond their potential for cell replacement, MSCs secrete a wide range of growth factors and cytokines and have recently been recognized for the…
Cross-α amyloids are an emerging class of functional peptide assemblies that underlie biofilm formation and antibiotic resistance in bacteria. Beyond their biological significance, synthetic cross-α architectures exhibit remarkable rigidity and piezo…
INTRODUCTION: Elevated levels of serum Vitamin D (VitD) and increased expression of its receptor on peripheral blood cells have been reported in individuals who have been exposed to HIV-1 yet remain seronegative (HESN). This study aimed to investigat…
Bacterial keratitis is a potentially blinding corneal infection, withandbeing the leading gram-positive and gram-negative pathogens, respectively. The increasing antimicrobial resistance among these pathogens necessitates the development of newer the…
INTRODUCTION: Periodontitis is a plaque-induced condition that causes irreparable damage to the supporting tissues of the teeth, and tobacco smoking is a recognized exacerbating and risk factor. Antibiotic-resistant bacteria are a consequence of anti…
() is a leading cause of human gastroenteritis worldwide and must overcome intestinal innate immunity, including antimicrobial peptide LL-37. However, howresponds to LL-37 remains unclear. Here, we showed thatinfection stimulates intestinal epithelia…
Bronchopulmonary dysplasia (BPD) is a chronic lung condition in preterm infants characterized by impaired alveolar development, disrupted vascular growth, and persistent inflammation. These alterations, which often arise from early exposure to mechan…
The limited selectivity of antimicrobial peptides (AMPs) can lead to unintended damage to healthy eukaryotic cells, a process strongly influenced by membrane physicochemical properties. Cholesterol (CHO) is a key regulator of lipid packing, membrane…
Innate immune-related genes are shaped by strong selection pressures due to host-pathogen co-evolution, yet the evolutionary trajectory of cathelicidin antimicrobial (AMP) gene is poorly understood. Despite their central role in innate immunity, the…
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic urinary disorder with unclear pathogenesis. Previous studies identified BTK as a hub gene potentially involved in IC/BPS. This study investigates BTK's role in mast cell (MC) activatio…
[This corrects the article DOI: 10.3389/froh.2025.1694969.].
BACKGROUND: Fluorescence photobiomodulation (FPB) is a treatment for canine dermatitis, yet no studies exist assessing its effect on canine keratinocytes in vitro. OBJECTIVES: To determine: (i) the anti-inflammatory and antimicrobial effect of FPB on…
To identify the differential properties of anti-microbial peptides (AMPs) and proteins in the burying beetle Nicrophorus quadripunctatus and the short sexton beetle Necrodes littoralis, we performed comparative transcriptomic analyses, quantified gen…
Antimicrobial resistance demands therapeutics that combine potent activity with low resistance potential. Ultrashort antimicrobial peptides (AMPs) are attractive due to their manufacturability and tunability, but activity is often lost upon sequence…
Bacterial extracellular vesicles (BEVs) serve as efficient drug-delivery vehicles for bioactive molecules including antimicrobial peptides (AMPs). In the present study, human cathelicidin-derived AMP LL37 was encapsulated in Streptococcus parauberis-…
Human cathelicidin peptide LL-37 is encoded by the CAMP gene and plays a key role in innate immunity. It maintains intestinal homeostasis through antibacterial, immunomodulation, and tissue repair functions. This paper reviews the multiple functions…
The rise of antimicrobial resistance (AMR) has outpaced the development of new antibiotics, necessitating alternative therapeutic strategies that do not rely on conventional bactericidal approaches. Quorum-sensing (QS), a bacterial communication syst…
BACKGROUND: During the COVID-19 pandemic, it became evident that an infection with SARS-CoV-2 is associated with an increased predisposition for thrombembolic events. Recent studies suggest an excessive neutrophil extracellular trap (NET)-formation i…