The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
() represents a major threat because of its multidrug resistance, achieved through its ability to control virulence, and its mechanisms of drug efflux resistance. In this study, we used a combined experimental-computational approach to create and eva…
The increasing prevalence of multidrug-resistant (MDR) bacterial infections poses global health challenges, highlighting the urgent need for new antimicrobial agents. The key advantages of antimicrobial peptides are their ability to rapid bactericida…
Transient receptor potential vanilloid 4 (TRPV4) is a polymodal cation channel that is widely expressed in sensory neurons, immune cells, and structural tissues, where it integrates mechanical, osmotic, and chemical stimuli to regulate both physiolog…
is a notorious opportunistic pathogen that causes life-threatening infections in immunocompromised individuals. In this study, we isolated two mucoid imipenem-resistantstrains, SCPa14 and SCPa16, from a single silicosis patient. Whole-genome sequenci…
INTRODUCTION: Antimicrobial peptides (AMPs) are essential components of the innate immune system, exhibiting diverse mechanisms of action. OBJECTIVE: This study investigates the roles of cathelicidin (LL-37), alpha-defensins, and the S100 proteins S1…
The growing global threat of antimicrobial resistance (AMR), particularly in cutaneous wound infections, represents a significant clinical and economic challenge. Biofilm formation by multidrug-resistant pathogens, such as, often complicates healing…
INTRODUCTION: Adipose-derived mesenchymal stem cells (ADSCs) have been widely investigated for their pro-angiogenic and immunomodulatory roles in the repair of infected wounds. However, the direct antimicrobial effects of ADSCs and the underlying reg…
Synergistic bactericidal effects between antimicrobial peptides (AMPs) have been widely studied, yet their cooperative roles in reducing host-cell cytotoxicity remain poorly understood. Inspired by the cross-seeding observed in α-synuclein and β-amyl…
The appearance of antibiotic-resistant strains of() is leading to a decreased eradication rate ofinfection. There is an urgent need to find new agents with antimicrobial mechanisms different from those of antibiotics, with therapeutic potential to cl…
The gastrointestinal tract hosts a diverse microbial community, named the intestinal microbiota, which plays a vital role in gut health. Host defense peptides (HDPs), such as defensins, help regulate interactions between the host and its microbiota.…
The fever response is triggered during infection and inflammation, but the importance of this response for the function of antimicrobial peptides (AMPs) remains unknown. We discovered that the activity of the human AMP LL-37 is temperature-dependent…
There is an urgent need for new antimicrobial agents to address the emerging antimicrobial resistance and the lack of novel antibiotics on the market. Antimicrobial peptides (AMPs) have gained significant interest as potential antibiotics over the pa…
Prevention and treatment of intramammary infections (IMI) associated with subclinical mastitis (SCM) are among the leading reasons for antimicrobial usage (AMU) in dairy cows, especially at dry-off. By adopting a selective dry cow therapy ((S)DCT), o…
BACKGROUND: Rosacea is a chronic inflammatory skin disease, with LL-37 driving inflammation. Inhibiting serine protease kallikrein-5 (KLK5) overactivity can reduce LL-37 production, thereby relieving this inflammation. Lithospermic acid (LA), a plant…
Trichomoniasis is the most prevalent non-viral sexually transmitted infection worldwide and is caused by. The development of resistance against the standard treatment, metronidazole, highlights the need for alternative therapeutic approaches. The rol…
Cancer cell migration is a key step in the metastatic cascade. Understanding its mechanisms represents one of the greatest challenges in modern oncology. Both in vitro and in vivo experimental models and mathematical descriptions of movement dynamics…
The terpenoid compounds geosmin (GSM) and 2-methylisoborneol (MIB), produced by a wide range of microorganisms, are abundant in many aquatic environments. Both compounds are easily detectable by humans (<5 ng/L), and they are often associated with an…
BACKGROUND: Rosacea episcleritis, scleritis and uveitis may be missed when clinicians focus on the eye without appraising the adnexae and facial skin. Addressing rosacea can reduce treatment failures and avoid systemic complications of less effective…
Klebsiella pneumoniae is one of the major pathogens responsible for multiple infections in clinical settings，and especially, the emergence of highly pathogenic variant known as hypervirulent K. pneumoniae (hvKp) poses an increasing threat to public h…