The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
To combat the growing challenge of bacterial infections, sonodynamic antibacterial technology has gained increasing attention. However, current approaches still face limitations, including suboptimal efficacy and a narrow antibacterial spectrum (only…
GF-17, the main antimicrobial domain of LL-37, exhibits optimal amphipathicity and heightened hydrophobicity, leading to increased hemolytic activity. A series of novel GF-17-like antimicrobial peptides (AMPs) were designed using lysine scanning to e…
There is an urgent need for new antimicrobial agents to address the emerging antimicrobial resistance and the lack of novel antibiotics on the market. Antimicrobial peptides (AMPs) have gained significant interest as potential antibiotics over the pa…
Cross-α amyloids are an emerging class of functional peptide assemblies that underlie biofilm formation and antibiotic resistance in bacteria. Beyond their biological significance, synthetic cross-α architectures exhibit remarkable rigidity and piezo…
Dysregulation of low-density lipoprotein (LDL) cholesterol is strongly correlated with the risk of metabolic dysfunction-associated steatotic liver disease. Endogenous molecules targeting LDL clearance play crucial roles in the progression of liver s…
Dynamic changes in lipid membrane composition are a common response to stress, often involving shifts in key lipid molecules. Phosphatidic acid (PA), a central precursor in lipid biosynthesis, accumulates when anionic phospholipid synthesis is blocke…
INTRODUCTION: Urinary catheterization frequently causes urinary tract infections and patient discomfort. While hydrogel coatings combining antibacterial and hydrophilic properties offer a potential solution, challenges such as uncontrolled antimicrob…
TLR-targeted immunotherapy represents a promising strategy for combating infectious diseases by initiating or enhancing protective antimicrobial immunity. Here, we identified the first frog-derived TLR2 and TLR4 agonist, Cathelicidin-Ka (Cath-Ka), fr…
INTRODUCTION: Activated polymorphonuclear neutrophils (PMN) release neutrophil extracellular traps (NETs) composed of a web-like DNA core, concomitant with nuclear histones, granular peptides and enzymes. NETs in human urine and their potential role…
BACKGROUND: Although caries is known to be influenced by diet and oral hygiene factors, susceptibility to the disease may be reduced by host factors, such as saliva antimicrobial peptides (AMPs). However, the relationship between salivary AMPs and ea…
The increasing prevalence of multidrug-resistant (MDR) bacterial infections poses global health challenges, highlighting the urgent need for new antimicrobial agents. The key advantages of antimicrobial peptides are their ability to rapid bactericida…
BACKGROUND: Rosacea is a chronic inflammatory skin disease, with LL-37 driving inflammation. Inhibiting serine protease kallikrein-5 (KLK5) overactivity can reduce LL-37 production, thereby relieving this inflammation. Lithospermic acid (LA), a plant…
Effective management of infected skin wounds remains a major clinical challenge, particularly as rising antibiotic resistance compromises conventional therapies. Antimicrobial peptides (AMPs) have emerged as promising alternatives, but their clinical…
Periodontitis, a multifactorial inflammatory disease driven by microbial dysbiosis, dysregulated immunity, and oxidative stress, demands therapeutic strategies that concurrently address interconnected pathological pathways. Here, a biomimetic lipid d…
Antimicrobial resistance (AMR) undermines the effectiveness of antibiotic treatment, and due to this, it now worldwide health concern. In general, antibiotics are used to control or combat bacteria, their widespread and irresponsible has contributed…
Prevention and treatment of intramammary infections (IMI) associated with subclinical mastitis (SCM) are among the leading reasons for antimicrobial usage (AMU) in dairy cows, especially at dry-off. By adopting a selective dry cow therapy ((S)DCT), o…
Despite causing fatal encephalitis and long-term neurological, cognitive, and behavioral impairments in survivors, no antiviral drugs are currently available to treat Japanese encephalitis virus (JEV) infections, highlighting the urgent need for effe…
Alzheimer's disease is mainly caused by two proteins, Tau and Amyloid-β. While there are several cures currently being explored for it, there is no cure yet for the disease progression and prevention, but only those to alleviate the symptoms. One of…
BACKGROUND: Immune system is regulated by circadian rhythms, which promote inflammation and facilitate pathogen elimination. Antimicrobial peptides secreted by milk somatic cells and mammary gland epithelial cells play a crucial role in protecting th…
Cathelicidins, a diverse family of host defence peptides (HDPs) in vertebrates, are recognized for their potential in combating resistant microorganisms and their varied biological functions. While extensive studies have focused on mammalian cathelic…