Nature|2004|Schneider M|11 citations
PMID: 15565135
14102 studies
Heart disease is a leading cause of death in newborn children and in adults. Efforts to promote cardiac repair through the use of stem cells hold promise but typically involve isolation and introduction of progenitor cells. Here, we show that the G-a…
BACKGROUND: To study the relationship between human thymosin β4 (Tβ4 )expression and biological factors regarding invasion, metastasis and prognosis of human non-small cell lung cancer (NSCLC). METHODS: Tβ4 expression was detected in samples of 76 pa…
OBJECTIVE: To develop gene expression profiles of young and old senescence-accelerated mouse (SAM) cochlea and identify genes responsible for aging-related hearing loss. METHODS: Gene micro-array slides containing 1101 mouse genes were hybridized to…
Thymosin beta4 (Tbeta4), a 5 kDa polypeptide, is a member of the beta-thymosin family. It acts as the principal intracellular G-actin sequestering peptide and exhibits extracellular functions in angiogenesis and wound healing. The N-terminus of Tbeta…
We can distinguish three kinds of ras genes i.e. H-ras, K-ras and N-ras, which are rated as ras-protooncogenes. The point mutations within ras genes are frequently detected in human malignancies and in experimentally induced tumors in animals. The ai…
The study of chemical composition and dough rheology changes in sieve-classified two fractions (up to 60 and 60-240 microm particles) of wheat flour was the subject of this study. The straight grade flours were obtained by the milling of three Polish…
Boronic esters incorporated into a poly(vinyl chloride) (PVC)-supported liquid membrane electrodes have displayed an anionic ionophore properties enabling their use in the potentiometric high-throughput screening procedures. These compounds belong to…
The results of studies on the use of corrole derivatives as a host ligand in the PVC liquid membrane electrodes and their ability for the potentiometric high-throughput discrimination of nitrophenol guests have been presented. The significance of par…
The transgenic potato clones of cultivar Irga with improved resistance to a necrotic strain of potato virus Y (PVY(N)) were subjected to heat treatment in order to determine their technological quality. The technological quality was determined on the…
Interactions of calf spleen purine nucleoside phosphorylase (PNP) with a non-typical substrate, 8-azaguanine (8-azaG), and a bisubstrate analogue inhibitor, 9-(2-phosphonylmethoxyethyl)-8-azaguanine (PME-azaG), were investigated by means of steady-st…
The combined craniocerebral trauma is accompanied by an impaired brain function in respect to regulating the entire organism and extends the neurohumoral processes of metabolism. The use of a bioregulator of the cytomedine class--epitalamin--is an ac…
Neoadjuvant chemotherapy was given to 105 patients with locally advanced breast cancer after incubation of cytostatics with autoplasma (APCT) and autoblood (AHCT). Most of them also received epithalamine after incubation with AHCT. That significantly…
Circadian rhythm of plasma melatonin concentrations in healthy elderly subjects was studied before and after a course treatment with Epithalamin (peptide preparation from the pineal gland). Epithalamin modulated the melatonin-producing function of th…
Mitotic index of type B spermatogonia in intact animals is characterized by a circadian rhythm. Mitotic index increased and its circadian rhythm disappeared after pinealectomy. Treatment with Epithalamin for 14 days restored the circadian rhythm. The…
The effect of epithalamin on circadian rhythms of thymic serum factor titers and melatonin concentrations in the blood of elderly people was studied. Course treatment with epithalamin modulated the rhythm of the thymic endocrine function. The increas…
Epithalamine produces a dose-dependent antioxidant effect in patients in the early stage of diabetic retinopathy (DR). Retinalamine normalizes the parameters of local hemostatic potential only under the conditions of completely restored antioxidant a…
In this pilot study, we evaluated the efficacy of interferon-alpha (IFN) plus Thymosin-alpha 1 (TA1) to that of IFN alone in naive patients with chronic hepatitis C. Twenty-two patients were randomized to receive interferon-alpha 2b (3 million units…
Dendritic cells (DCs) show a remarkable functional plasticity in the recognition of Aspergillus fumigatus and orchestrate the antifungal immune resistance in the lungs. Here, we show that thymosin alpha 1, a naturally occurring thymic peptide, induce…