Effects of pineal peptides on circadian dynamics of spermatogonia proliferation in albino rats.

Bulletin of experimental biology and medicine2004PMID: 15455095

Animal StudyEpitalon

Plain Language Summary

After pinealectomy in rats, the normal circadian rhythm of spermatogonia proliferation was lost and the mitotic index increased. Treatment with Epithalamin for 14 days restored the circadian rhythm, demonstrating the pineal gland's role in regulating spermatogenesis through its peptide factors.

Abstract

Mitotic index of type B spermatogonia in intact animals is characterized by a circadian rhythm. Mitotic index increased and its circadian rhythm disappeared after pinealectomy. Treatment with Epithalamin for 14 days restored the circadian rhythm. The circadian biorhythm of spermatogonia proliferation suggests the presence of circadian rhythm of spermatogenesis in general and its regulation by the pineal gland.

Authors

Arav, V I; Sych, V F; Zheleznyak, E V; Slesarev, S M