Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people.

Bulletin of experimental biology and medicine2004PMID: 15452611

Randomized Controlled TrialEpitalon

Plain Language Summary

Epithalamin modulated pineal melatonin production in healthy elderly subjects in a normalizing manner. In those with initially low pineal activity, nighttime melatonin levels increased after treatment, while in those with already normal function, melatonin levels tended to decrease, suggesting a regulatory rather than purely stimulatory effect.

Abstract

Circadian rhythm of plasma melatonin concentrations in healthy elderly subjects was studied before and after a course treatment with Epithalamin (peptide preparation from the pineal gland). Epithalamin modulated the melatonin-producing function of the pineal gland. During the dark period plasma melatonin concentration increased in subjects with initially lowered activity of the pineal gland, while in subjects with normal epiphyseal function plasma melatonin concentration tended to decrease.

Authors

Korkushko, O V; Khavinson, V Kh; Shatilo, V B; Magdich, L V