[Optimal conditions for producing immunomodulating effect of epithalamine as component of neoadjuvant chemotherapy using autoplasma and autoblood in patients with locally advanced breast cancer].

Voprosy onkologii2004PMID: 15318714

Plain Language Summary

Epithalamin significantly improved cellular immunity parameters including T-cell content, subset distribution, and function when used alongside neoadjuvant chemotherapy in patients with locally advanced breast cancer. The most favorable immunomodulating effects were observed when Epithalamin was combined with autoblood chemotherapy, regardless of the specific chemotherapy regimen used.

Abstract

Neoadjuvant chemotherapy was given to 105 patients with locally advanced breast cancer after incubation of cytostatics with autoplasma (APCT) and autoblood (AHCT). Most of them also received epithalamine after incubation with AHCT. That significantly improved such parameters of cellular immunity as T-cell content, their subset distribution and function. The most favorable changes were observed when epithalamine was used in conjunction with AHCT. A similar immuno-modulating effect was exerted when epithalamine was used irrespective of either CMAV or CMFV regimens.

Authors

Zlamnik, E Iu; Vladimirova, L Iu; Zakora, G I