15038 studies
Thymosin α1 (Tα1) is an endogenous thymic peptide that enhances immune competence through activation of T cells, dendritic cells, and innate immune pathways. However, its direct impact on CD8T cell-mediated antitumor immunity in breast cancer remains…
To report a case of a nasopharyngeal carcinoma patient who developed multisystem immune-related adverse events (irAEs) after treatment with sintilimab (PD-1 inhibitor) in combination with thymosin alpha-1 (Tα1). The patient presents with high fever,…
BACKGROUND: Neoadjuvant immunochemotherapy has emerged as a promising strategy for locally advanced gastric and gastroesophageal junction (G/EGJ) adenocarcinoma, but a substantial proportion of patients derive limited benefit. Thymalfasin is an immun…
Viral reservoir presents a significant challenge in HIV-1 cure. We previously observed that Thymosin α1 (Tα1) may restrict the reservoir through the IL-15 pathway. However, the precise mechanism remains to be fully elucidated. Peripheral blood mononu…
BACKGROUND AND AIM: CD8T cell immunosenescence drives hepatocellular carcinoma (HCC) progression and impedes therapeutic efficacy. We hypothesized that combining interleukin-15 (IL-15), which rescues senescent CD8T cells peripherally, with thymosin a…
BACKGROUND: Thymosin α1 (Tα1) has been shown to improve survival in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), but its immunomodulatory mechanisms remain unclear. This study investigated how Tα1 restores immu…
Transient receptor potential vanilloid 4 (TRPV4) is a polymodal cation channel that is widely expressed in sensory neurons, immune cells, and structural tissues, where it integrates mechanical, osmotic, and chemical stimuli to regulate both physiolog…
The appearance of antibiotic-resistant strains of() is leading to a decreased eradication rate ofinfection. There is an urgent need to find new agents with antimicrobial mechanisms different from those of antibiotics, with therapeutic potential to cl…
Prevention and treatment of intramammary infections (IMI) associated with subclinical mastitis (SCM) are among the leading reasons for antimicrobial usage (AMU) in dairy cows, especially at dry-off. By adopting a selective dry cow therapy ((S)DCT), o…
BACKGROUND: Visceral fat (VF), particularly epicardial adipose tissue (EAT), plays a crucial role in the development of coronary artery disease (CAD). Cathelicidin (LL37) is an antimicrobial peptide involved in innate immunity and has been implicated…
Cancer cell migration is a key step in the metastatic cascade. Understanding its mechanisms represents one of the greatest challenges in modern oncology. Both in vitro and in vivo experimental models and mathematical descriptions of movement dynamics…
INTRODUCTION: Activated polymorphonuclear neutrophils (PMN) release neutrophil extracellular traps (NETs) composed of a web-like DNA core, concomitant with nuclear histones, granular peptides and enzymes. NETs in human urine and their potential role…
Dynamic changes in lipid membrane composition are a common response to stress, often involving shifts in key lipid molecules. Phosphatidic acid (PA), a central precursor in lipid biosynthesis, accumulates when anionic phospholipid synthesis is blocke…
BACKGROUND: Immune system is regulated by circadian rhythms, which promote inflammation and facilitate pathogen elimination. Antimicrobial peptides secreted by milk somatic cells and mammary gland epithelial cells play a crucial role in protecting th…
The double cooperative effect between two major antimicrobial peptides, LL-37 and HNP1, where their combination enhances antimicrobial efficiency while reducing cytotoxicity, offers a promising strategy for developing safer and more effective antibio…
Inflammatory bowel disease (IBD) represents a chronic relapsing disorder driven by a loss of homeostatic balance between the host immune system and the intestinal microbiota. Endogenous antimicrobial peptides (AMPs), produced primarily by epithelial…
INTRODUCTION: Antimicrobial peptides (AMPs) hold promises to counter antimicrobial resistance. They cause several deleterious effects in bacterial cells by interfering with cell wall biosynthesis, DNA replication, transcription, and translation. OBJE…
Despite causing fatal encephalitis and long-term neurological, cognitive, and behavioral impairments in survivors, no antiviral drugs are currently available to treat Japanese encephalitis virus (JEV) infections, highlighting the urgent need for effe…
The host-defense peptide cathelicidin LL37 is an innate immune defense peptide with broad-spectrum antimicrobial effects. Experiments showed that the antimicrobial activity of LL37(17-29), the active core of LL37, was associated with peptide aggregat…
[This corrects the article DOI: 10.3389/fmicb.2026.1770133.].