Studies

Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu.

Bioorganic & medicinal chemistry|2008|Chen Y et al.

Two tripeptides H-Asp(Arg)-Arg (3a) and H-Glu(Arg)-Arg (3b), four pentapeptides H-Asp(Arg-Asp)-Arg-Asp (6a), H-Glu(Arg-Asp)-Arg-Asp (6b), H-Asp(Asp- Arg)-Asp-Arg (10a), and H-Glu(Asp-Arg)-Asp-Arg (10b), and their Cu(II)-peptide complexes Cu(II)-Asp(A…

Animal StudyPinealon

PMID: 18495483

The next generation of human growth hormone. How Serostim and tesamorelin measure up.

Positively aware : the monthly journal of the Test Positive Aware Network|2008|Grodeck B

Tesamorelin

Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation.

AIDS (London, England)|2008|Falutz J et al.

OBJECTIVE: Treatment of HIV patients with daily tesamorelin, a growth hormone-releasing factor analogue, for 26 weeks resulted in a significant decrease in visceral adipose tissue (VAT) and improvement in lipids. The objective of the 26-week extensio…

Randomized Controlled TrialTesamorelin

PMID: 18690162

[Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice].

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova|2008|Sarkisova K, Kozlovskiĭ I, Kozlovskaia M

A synthetic derivative of the endogenous peptide tuftsin heptapeptide selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) possesses an anxiolytic and psychostimulant effect, and represents a working element of a new peptide drug having completed the third phase of…

Animal StudySelank

PMID: 18661785

[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova|2008|Uchakina O et al.

The purpose of this article was to study the immunotropic effects of the new neurotrophic heptapeptide selank. The experiments in vitro revealed that the drug in concentration 10-7 M completely suppressed gene expression by peripheral blood IL-6 of p…

Animal StudyIn VitroSelank

PMID: 18577961

[Compensatory effect of selank on the mnestic functions disturbed by neurotoxic damage of the noradrenergic system of the rat brain].

Eksperimental'naia i klinicheskaia farmakologiia|2008|Kozlovskiĭ I et al.

It has been shown that the peptide anxiolytic drug Selank recovers learning and memory impaired by damage of the noradrenergic (NA) brain system in Wistar rats after injection of the NA-synthesis inhibitor disulfiram, administration of neurotoxic com…

Animal StudySelank

PMID: 18488898

[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova|2008|Zozulia A et al.

Sixty-two patients with generalized anxiety disorder (GAD) and neurasthenia were studied. The effect of selank (30 patients) was compared to that of medazepam (32 patients). Patient's state was assessed with psychometric scales (Hamilton, Zung, CGI).…

Randomized Controlled TrialSelank

PMID: 18454096

Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from antenatal hypoxia.

Neuroscience and behavioral physiology|2008|Semenova T et al.

The effects of Selank, the active component of which is the heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro, which includes the tetrapeptide tuftsin and three natural levorotatory amino acids, on behavior and brain serotonin and noradrenaline levels were st…

Animal StudySelank

PMID: 18197389

[Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study].

Eksperimental'naia i klinicheskaia farmakologiia|2008|Narkevich V et al.

The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied. Significant interstrain differences in t…

Animal StudySelank

PMID: 19093364

Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections|2008|Inozemtseva L et al.

Animal StudySelank

PMID: 18841804

[Compensatory and antiamnestic effects of heptapeptide Selank in monkeys].

Zhurnal evoliutsionnoi biokhimii i fiziologii|2008|Unknown authors

The work presents results of study of role of heptapeptide Selank--an anxiolytic from group of biologically active peptides--in compensation of disturbed psychic and homeostatic functions in monkeys. New data have been obtained which indicate that an…

Selank

PMID: 18727417

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology|2008|Tomillero A, Moral M

(+)-Dapoxetine hydrochloride, (R)-Etodolac; Abatacept, ABT-510, Adalimumab, Agatolimod sodium, Alemtuzumab, Alvocidib hydrochloride, Aminolevulinic acid methyl ester, Aripiprazole, AS01B, AS02B, AS02V, Azacitidine; Becatecarin, Bevacizumab, Bevirimat…

PT-141

PMID: 18806898

Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro.

British journal of pharmacology|2008|Aughton K et al.

BACKGROUND AND PURPOSE: Hypothalamic neuropeptides centrally modulate sexual arousal. However, the role of neuropeptides in peripheral arousal has been ignored. Vascular and non-vascular smooth muscle relaxation in the vagina is important for female…

Animal StudyIn VitroPT-141

PMID: 18587425

Clinical applications of centrally acting agents in male sexual dysfunction.

International journal of impotence research|2008|Hellstrom W

Currently available agents for erectile dysfunction (ED) share the same mechanism of action and pharmacologic properties. Therefore, they share the same limitations, including a principal focus on erection as an end-organ process. One of the relative…

ReviewPT-141

PMID: 18552830

Preclinical effects of melanocortins in male sexual dysfunction.

International journal of impotence research|2008|Shadiack A, Althof S

The neurobiology of sexual behavior involves the interrelationships between sex steroids and neurotransmitters that result in both central nervous system (CNS) effects and effects in the genitalia. Tools such as positron emission tomography (PET) and…

ReviewPT-141

PMID: 18552829

Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study.

The Journal of urology|2008|Safarinejad M, Hosseini S

PURPOSE: We evaluated the safety and efficacy of intranasal bremelanotide in men with erectile dysfunction who did not respond to sildenafil. MATERIALS AND METHODS: A total of 342 married men (28 to 59 years old) with erectile dysfunction who did not…

Randomized Controlled TrialPT-141

PMID: 18206919

RETRACTED: Evaluation of the safety and efficacy of bremelanotide, a melanocortin receptor agonist, in female subjects with arousal disorder: a double-blind placebo-controlled, fixed dose, randomized study.

The journal of sexual medicine|2008|Safarinejad M

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Following the retracti…

Randomized Controlled TrialPT-141

PMID: 18179455

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology|2008|Tomillero A, Moral M

Gateways to clinical trials is a guide to the most recent trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity(R), the drug discovery and d…

PT-141

PMID: 19088949

Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system.

Journal of pharmacological sciences|2008|Klicek R et al.

We focused on the therapeutic effect of the stable gastric pentadecapeptide BPC 157 and how its action is related to nitric oxide (NO) in persistent colocutaneous fistula in rats (at 5 cm from anus, colon defect of 5 mm, skin defect of 5 mm); this pe…

Animal StudyBPC-157

PMID: 18818478

Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu.

The next generation of human growth hormone. How Serostim and tesamorelin measure up.

Tesamorelin for fat accumulation. 52-week effects and safety of tesamorelin (growth hormone releasing factor) in HIV patients with fat accumulation.

Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation.

[Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice].

[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].

[Compensatory effect of selank on the mnestic functions disturbed by neurotoxic damage of the noradrenergic system of the rat brain].

[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].

Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from antenatal hypoxia.

[Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study].

Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo.

[Compensatory and antiamnestic effects of heptapeptide Selank in monkeys].

Gateways to clinical trials.

Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro.

Clinical applications of centrally acting agents in male sexual dysfunction.

Preclinical effects of melanocortins in male sexual dysfunction.

Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study.

RETRACTED: Evaluation of the safety and efficacy of bremelanotide, a melanocortin receptor agonist, in female subjects with arousal disorder: a double-blind placebo-controlled, fixed dose, randomized study.

Gateways to clinical trials.

Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system.