A synthetic analog of the immunomodulatory peptide tuftsin, studied for anxiolytic and nootropic effects.
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews|2026|Rahman O, Lee S, Seeds W
Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine. By acting on key pathways such as PI3K/Akt, mTOR, MAPK…
Review
PMID: 41490200
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
Bulletin of experimental biology and medicine|2022|Konstantinopolsky M, Chernyakova I, Kolik L
Activity of a peptide tuftsin analogue Selank was studied in outbred rats using the naloxone-precipitated morphine withdrawal model. Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine wit…
Animal Study
PMID: 36322304
The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.
Current reviews in clinical and experimental pharmacology|2021|Leonidovna Y et al.
BACKGROUND: It was previously thought that inflammation and an immune response were the only factors capable of causing IL-1β, IL-6 and other cytokine`s production. In recent years data have appeared that stressful effects can also occupy an importan…
Animal Study
PMID: 32621722
Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.
Journal of clinical pharmacology|2021|Doyno C, White C
There are many nonopioid central nervous system depressant substances that share a gamma-aminobutyric acid (GABA) receptor-related mechanism of action. These sedatives-hypnotics can be indicated to treat anxiety, seizures, depression, and insomnia bu…
PMID: 34396551
The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.
Drug testing and analysis|2020|Vanhee C et al.
At the end of 2017 and 2018 two different unknown suspicious preparations were encountered and were subjected to a plethora of different analyses in order to identify, if present, any bioactive compound. It turned out that these samples contained the…
PMID: 31667971
Functional Connectomic Approach to Studying Selank and Semax Effects.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections|2020|Panikratova Y et al.
The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants. The ROIs…
PMID: 32342318
Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank.
Bulletin of experimental biology and medicine|2020|Mukhina A et al.
We studied the effects of Selank on the condition of the colon wall in Wistar male rats subjected to restraint stress. Selank was injected intraperitoneally in doses of 80, 250, and 750 μg/kg 15 min before stress exposure. In rats subjected to stress…
Animal Study
PMID: 32651826
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.
Bulletin of experimental biology and medicine|2019|Kolik L et al.
The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol…
Animal Study
PMID: 31625062
Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.
Bulletin of experimental biology and medicine|2019|Fomenko E et al.
We studied the effects of Selank on morphological parameters of the liver in Wistar male rats subjected to chronic foot-shock stress. Selank was injected intraperitoneally in doses of 100, 300 and 1000 μg/kg 15 min before each stress session. Morphol…
Animal Study
PMID: 31243679
State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.
Bulletin of experimental biology and medicine|2019|Mukhina A et al.
We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint stress led t…
Animal Study
PMID: 31236882
Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.
Protein and peptide letters|2018|Vyunova T et al.
BACKGROUND: Anxiety and mood disorders are the most abundant mental health problems worldwide. The commonly used in clinical practice anxiolytics are focused on pharmacological modulation of brain GABA receptor system activity. As a rule, their use p…
PMID: 30255741
Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells.
Bulletin of experimental biology and medicine|2017|Kobylyanskii A et al.
We studied the effects of peptide drugs (HLDF-6, PGP, RPGP, and PGLP) and peptide pharmaceutical products (Semax, Selank, and thyroliberin) on proliferation and survival of mouse embryonic stem cells and their derivatives. Differentiation of mouse em…
Animal Study
PMID: 29063333
Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.
Bulletin of experimental biology and medicine|2017|Fomenko E et al.
We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity…
Animal Study
PMID: 28853100
Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.
Bulletin of experimental biology and medicine|2017|Povarov I et al.
Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontane…
Animal Study
PMID: 28361410
Tuftsin - Properties and Analogs.
Current medicinal chemistry|2017|Siebert A et al.
BACKGROUND: Immunomodulation is one of the significant therapeutic strategies. It includes both stimulation and suppression of the immune system by a variety of substances called immunomodulators, designed to regulate the immune response of the organ…
Review
PMID: 28745220
GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.
Frontiers in pharmacology|2017|Filatova E et al.
Clinical studies have shown that Selank had an anxiolytic effect comparable to that of classical benzodiazepine drugs, which can enhance the inhibitory effect of GABA by allosteric modulation of GABAreceptors. These data suggest that the molecular me…
PMID: 28293190
Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography.
Bulletin of experimental biology and medicine|2017|Rogozinskaya E, Lyapina M
Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypoco…
PMID: 29181670
Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections|2017|Slominsky P et al.
Parkinson's disease (PD) is the second most common severe neurodegenerative disorder that is characterized by progressive degeneration of dopaminergic neurons (DA neurons) in the substantia nigra pars compacta (SNpc) region of the brain. In the prese…
Animal Study
PMID: 28702721
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats.
Behavioural neurology|2017|Kasian A et al.
It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classica…
Animal Study
PMID: 28280289
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.
Frontiers in pharmacology|2016|Volkova A et al.
Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam. These data suggest that there is a similar basis of their mechanism of action. To test this…
Animal Study
PMID: 26924987