A tripeptide (Glu-Asp-Arg) derived from the pineal gland, studied for neuroprotective properties, cognitive enhancement, and anti-aging effects.
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews|2026|Rahman O, Lee S, Seeds W
Therapeutic peptides are emerging as promising adjuncts in the management of orthopaedic injuries, grounded in their ability to modulate molecular signaling networks central to cellular medicine. By acting on key pathways such as PI3K/Akt, mTOR, MAPK…
Review
PMID: 41490200
Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.
International journal of molecular sciences|2024|Kraskovskaya N et al.
Neurons become more vulnerable to stress factors with age, which leads to increased oxidative DNA damage, decreased activity of mitochondria and lysosomes, increased levels of p16, decreased LaminB1 proteins, and the depletion of the dendritic tree.…
In Vitro
PMID: 39518916
[Prospects for use of short peptides in pharmacotherapeutic correction of Alzheimer's disease.].
Advances in gerontology = Uspekhi gerontologii|2024|Ilina A et al.
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by progressive cognitive decline. This review discusses current therapeutic strategies for the treatment of Alzheimer's disease, their limitations, and potential pr…
Review
PMID: 38944767
The Role of Amino Acids in the Diagnosis, Risk Assessment, and Treatment of Breast Cancer: A Review.
Current issues in molecular biology|2023|Bel'skaya L, Gundyrev I, Solomatin D
This review summarizes the role of amino acids in the diagnosis, risk assessment, imaging, and treatment of breast cancer. It was shown that the content of individual amino acids changes in breast cancer by an average of 10-15% compared with healthy…
Review
PMID: 37754258
Effect of seabuckthorn seed protein and its arginine-enriched peptides on combating memory impairment in mice.
International journal of biological macromolecules|2023|Zhu X et al.
The current study characterized the combating memory impairment effect of seabuckthorn seed protein (SSP) and the arginine (Arg)-enriched peptides (SSPP) on d-galactose-induced brain aging in mice. The Arg content in SSP and SSPP were 10.11 and 17.82…
Animal Study
PMID: 36706884
Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease.
Pharmaceuticals (Basel, Switzerland)|2021|Khavinson V et al.
KED and EDR peptides prevent dendritic spines loss in amyloid synaptotoxicity in in vitro model of Alzheimer's disease (AD). The objective of this paper was to study epigenetic mechanisms of EDR and KED peptides' neuroprotective effects on neuroplast…
Animal StudyIn Vitro
PMID: 34071923
EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease.
Molecules (Basel, Switzerland)|2020|Khavinson V et al.
The EDR peptide (Glu-Asp-Arg) has been previously established to possess neuroprotective properties. It activates gene expression and synthesis of proteins, involved in maintaining the neuronal functional activity, and reduces the intensity of their…
ReviewAnimal StudyIn Vitro
PMID: 33396470
Radiolabelling of lipid-based nanocarriers with fluorine-18 for in vivo tracking by PET.
Colloids and surfaces. B, Biointerfaces|2020|Nagachinta S et al.
Organic nanoparticles made out of biodegradable and biocompatible materials have attracted increased attention in the therapeutic and diagnostic fields. In this study, we attempted to explore a new radiolabelling chelating free strategy for biodegrad…
Animal Study
PMID: 31982792
Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction.
The journal of physical chemistry. B|2019|Silanteva I et al.
The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods. It was shown that EDR can partly penetrate into the major groove of DNA and affect…
PMID: 30762356
[Comparative analysis of different methods of geroprotective].
Advances in gerontology = Uspekhi gerontologii|2016|Myakotnykh V et al.
In the monitoring process 110 representatives of different age groups held a comparative analysis of the efficacy and safety of several geroprotective techniques, including the use of dry carbon dioxide baths, hyperbaric oxygen therapy, therapeutic m…
PMID: 28539017
Short Peptides and Telomere Length Regulator Hormone Irisin.
Bulletin of experimental biology and medicine|2016|Khavinson V et al.
Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and A…
PMID: 26742748
[Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].
Advances in gerontology = Uspekhi gerontologii|2015|Mendzheritsky A et al.
The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held. The peculiarities of peptide preparations' influence on behavior and neurochemical indeces have…
Animal Study
PMID: 28509493
Angiotensin II restricted analogs with biological activity in the erythrocytic cycle of Plasmodium falciparum.
Journal of peptide science : an official publication of the European Peptide Society|2015|Torres M et al.
The anti-plasmodial activity of conformationally restricted analogs of angiotensin II against Plasmodium gallinaceum has been described. To observe activity against another Plasmodium species, invasion of red blood cells by Plasmodium falciparum was…
PMID: 25420772
[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].
Advances in gerontology = Uspekhi gerontologii|2015|Meshchaninov V et al.
We've estimated the cellular and metabolic part of geroprophylactic effects of short synthetic tripeptides vesugen and pinealon for correction of the biological age. 32 people (18 men, 12 women) aged 41-83 years with polymorbidity and the organic bra…
PMID: 26390612
[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].
Advances in gerontology = Uspekhi gerontologii|2014|Mendzheritskiĭ A et al.
While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of b…
Animal Study
PMID: 25051764
Short peptides stimulate serotonin expression in cells of brain cortex.
Bulletin of experimental biology and medicine|2014|Khavinson V et al.
Peptides Glu-Asp-Arg and Lys-Glu-Asp stimulate serotonin expression in aging cultures of brain cortex cells. Peptide regulation of 5-tryptophan hydroxylase gene encoding the enzyme involved in serotonin synthesis was demonstrated by the molecular doc…
PMID: 24909721
[Effect of peptide geroprotectors on the navigation system learning and caspase-3 in brain structures in rats of different age].
Advances in gerontology = Uspekhi gerontologii|2013|Mendzheritski A et al.
The study of the effects of peptide geroprotectors cortexin and pinealon on the system of caspase-3 in the brain structures and training of rats of different ages was held. Regional changes in activity and the content of caspase-3 in the cerebral cor…
Animal Study
PMID: 28976148
Interaction of short peptides with FITC-labeled wheat histones and their complexes with deoxyribooligonucleotides.
Biochemistry. Biokhimiia|2013|Fedoreyeva L et al.
Judging from fluorescence modulation (quenching), short peptides (Ala-Glu-Asp-Gly, Glu-Asp-Arg, Ala-Glu-Asp-Leu, Lys-Glu-Asp-Gly, Ala-Glu-Asp-Arg, and Lys-Glu-Asp-Trp) bind with FITC-labeled wheat histones H1, H2B, H3, and H4. This results from the i…
PMID: 23581987
[Neuroprotective effects of peptides bioregulators in people of various age].
Advances in gerontology = Uspekhi gerontologii|2013|Umnov R, Lin'kova N, Khavinson V
The review presents comparative characteristics of 2 peptide neuroprotective groups: polypeptide complexes (cortexin, cerebrolizin) and short peptides (semax, kortagen, pinealon). The data of clinical applying of peptides in elderly and old age peopl…
Review
PMID: 24738258
[The peptide correction of neurotic disorders among professional truck-drivers].
Advances in gerontology = Uspekhi gerontologii|2012|Bashkireva A, Artamonova V
This study was designed to estimate the neurobehavioral status and to compare the prevalence of psychoadaptive disorders among lorry-drivers (experimental group) and metal craftsmen (control group) in connection with their age, length of service, occ…
Clinical Trial
PMID: 23734521