Studies | Pepdox

Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial.

Neurology|2023|Karaa A et al.

BACKGROUND AND OBJECTIVES: Primary mitochondrial myopathies (PMMs) encompass a group of genetic disorders that impair mitochondrial oxidative phosphorylation, adversely affecting physical function, exercise capacity, and quality of life (QoL). Curren…

Randomized Controlled TrialSS-31

PMID: 37268435

SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop.

The journal of headache and pain|2023|Shan Z et al.

Migraine is the second highest cause of disability worldwide, bringing a huge socioeconomic burden. Improving mitochondrial function has promise as an effective treatment strategy for migraine. Szeto-Schiller peptide (SS-31) is a new mitochondria-tar…

Temporal evolution of the heart failure phenotype in Barth syndrome and treatment with elamipretide.

Future cardiology|2023|Sabbah H, Taylor C, Vernon H

Barth syndrome (BTHS) is a rare genetic disorder caused by pathogenic variants inleading to reduced remodeled cardiolipin (CL), a phospholipid essential to mitochondrial function and structure. Cardiomyopathy presents in most patients with BTHS, typi…

ReviewSS-31

PMID: 37325898

A Triple-Targeted Rutin-Based Self-Assembled Delivery Vector for Treating Ischemic Stroke by Vascular Normalization and Anti-Inflammation via ACE2/Ang1-7 Signaling.

ACS central science|2023|Zhao T et al.

Changes in the cerebral microenvironment caused by acute ischemic stroke-reperfusion are the main obstacle to the recovery of neurological function and an important cause of stroke recurrence after thrombolytic therapy. The intracerebral microenviron…

SS-31

PMID: 37396868

Age and sex dependent effects of metabolic response to muscle contraction.

bioRxiv : the preprint server for biology|2023|Campbell M et al.

Sarcopenia, the age-related loss of muscle mass and function, contributes to decreased quality of life in the elderly and increased healthcare costs. Decreased skeletal muscle mass, specific force, increased overall fatty depositions in the skeletal…

Animal StudySS-31

PMID: 37398086

The emerging significance of mitochondrial targeted strategies in NAFLD treatment.

Life sciences|2023|Zhang T, Nie Y, Wang J

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide, ranging from liver steatosis to nonalcoholic steatohepatitis, which ultimately progresses to fibrosis, cirrhosis, and hepatocellular carcinoma. Individual…

ReviewSS-31

PMID: 37454757

Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels.

GeroScience|2023|Seman A et al.

Cognitive impairment and dementias during aging such as Alzheimer's disease are linked to functional decline and structural alterations of the brain microvasculature. Although mechanisms leading to microvascular changes during aging are not clear, lo…

Animal StudySS-31

PMID: 37458933

The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).

GeroScience|2023|Pharaoh G et al.

Aging muscle experiences functional decline in part mediated by impaired mitochondrial ADP sensitivity. Elamipretide (ELAM) rapidly improves physiological and mitochondrial function in aging and binds directly to the mitochondrial ADP transporter ANT…

Animal StudySS-31

PMID: 37462785

Cardiolipin-mediated temporal response to hydroquinone toxicity in human retinal pigmented epithelial cell line.

Biochimica et biophysica acta. Molecular cell research|2023|Davidescu M et al.

Hydroquinone, a potent toxic agent of cigarette smoke, damages retinal pigmented epithelial cells by triggering oxidative stress and mitochondrial dysfunction, two events causally related to the development and progression of retinal diseases. The in…

In VitroSS-31

PMID: 37524263

Validation of a Reduced Set of High-Performance Triggers for Identifying Patient Safety Incidents with Harm in Primary Care: TriggerPrim Project.

Journal of patient safety|2023|Garzón González G et al.

OBJECTIVE: The aim of the study was to construct and validate a reduced set of high-performance triggers for identifying adverse events (AEs) via electronic medical records (EMRs) review in primary care (PC). METHODS: This was a cross-sectional descr…

SS-31

PMID: 37707868

Peptide Power: Mechanistic Insights into the Effect of Mitochondria-Targeted Tetrapeptides on Membrane Electrostatics from Molecular Simulations.

Molecular pharmaceutics|2023|Tamucci J, Alder N, May E

Mitochondrial dysfunction is implicated in nine of the ten leading causes of death in the US, yet there are no FDA-approved therapeutics to treat it. Synthetic mitochondria-targeted peptides (MTPs), including the lead compound SS-31, offer promise, a…

SS-31

PMID: 37904323

Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP).

Ecotoxicology and environmental safety|2023|Zhang H et al.

Di-2-ethylhexyl phthalate (DEHP), as a common endocrine disrupting chemicals, can induce toxicity to reproductive system. However, the mechanism remains to be explored. In our study, DEHP exposure induced testicular injury in rats. The high throughpu…

Animal StudyIn VitroSS-31

PMID: 37979351

Elamipretide(SS-31) Attenuates Idiopathic Pulmonary Fibrosis by Inhibiting the Nrf2-Dependent NLRP3 Inflammasome in Macrophages.

Antioxidants (Basel, Switzerland)|2023|Nie Y et al.

Idiopathic pulmonary fibrosis (IPF) is a progressive fatal lung disease with a limited therapeutic strategy. Mitochondrial oxidative stress in macrophages is directly linked to IPF. Elamipretide(SS-31) is a mitochondrion-targeted peptide that has bee…

Animal StudySS-31

PMID: 38136142

Proteomic Analysis of Hepatic Fibrosis in Human Immunodeficiency Virus-Associated Nonalcoholic Fatty Liver Disease Demonstrates Up-regulation of Immune Response and Tissue Repair Pathways.

The Journal of infectious diseases|2023|Fourman L et al.

BACKGROUND: Human immunodeficiency virus (HIV)-associated nonalcoholic fatty liver disease (NAFLD) is characterized by a high prevalence of hepatic fibrosis as a strong clinical predictor of all-cause and liver-specific mortality risk. METHODS: We le…

Tesamorelin

PMID: 36461941

Effect of dietary inclusion of mealworm frass on growth, hematology, and serum biochemistry of sheep.

Tropical animal health and production|2023|Ayaz M et al.

Frass is the main component of worm by-product which exhibit anti-microbial and anti-pathogenic properties. In the present study, we assessed the possibility of mealworm frass in sheep feeding regime and evaluated its effect on health and growth perf…

Selank

PMID: 36881277

Increase in False-Positive Fourth-Generation Human Immunodeficiency Virus Tests in Patients With Coronavirus Disease 2019.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America|2023|Gudipati S et al.

BACKGROUND: We observed an increase in the frequency of false-positive (FP) human immunodeficiency virus (HIV) test results that correlated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) prevalence. We measured FP rates of laborato…

Selank

PMID: 37158382

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development.

Cardiovascular research|2023|Seibertz F et al.

AIMS: Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology alterations which promote AF chronification and treatment resistance. Development of novel antiarrhythmic therapies is hampered by the absence of scalabl…

In VitroSelank

PMID: 37677054

Tirzepatide suppresses palatable food intake by selectively reducing preference for fat in rodents.

Diabetes, obesity & metabolism|2023|Geisler C et al.

AIM: To investigate the role of glucose-dependent insulinotropic polypeptide receptor (GIPR) agonists alone or combined with glucagon-like peptide-1 receptor (GLP-1R) agonists to regulate palatable food intake and the role of specific macronutrients…

Animal StudyTirzepatide

PMID: 36054312

Tirzepatide: A New Anti-Obesity Medication.

Gastroenterology|2023|Ghoneim S

Tirzepatide

PMID: 36155186

Change in pharmacodynamic variables following once-weekly tirzepatide treatment versus dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono substudy).

Diabetes, obesity & metabolism|2023|Yabe D et al.

AIM: To evaluate the pharmacodynamic effects of tirzepatide, a novel dual glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor agonist, compared with dulaglutide in patients with type 2 diabetes. MATERIALS AND ME…

Randomized Controlled TrialTirzepatide

PMID: 36184780