The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
INTRODUCTION: The constantly growing resistance of bacteria causing bloodstream infections and the lack of alternative antibiotics generate the need to develop new therapeutic strategies. In this study, the antibacterial properties of synthetic choli…
The objectives of the present work were as follows: (i) the detection of cathelicidin biomolecules in the milk of individual goats during the early stages of mastitis and their potential use for the diagnosis of mastitis at its early stage and (ii) t…
BACKGROUND: Diosgenin, a well-known steroid sapogenin, has demonstrated anti-inflammatory effects; however, its therapeutic potential for sepsis remains unclear. Intestinal barrier dysfunction is a critical contributor to lethal sepsis, a systemic in…
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb) and is a growing public health problem worldwide. Within the innate immune response, we highlight the secretion of the antimicrobial peptide LL-37, which is crucial for…
The bidirectional correlation between diabetes and periodontitis positions the latter as the most prevalent complication of the former. Rehabilitation of the periodontal tissues damaged by diabetic periodontitis presents a significant clinical challe…
UNLABELLED: Bacteriaewlyeased (NRel) from biofilm residence via multiple methodologies are commonly significantly more sensitive to antibiotics. We've induced NRel with this phenotype after incubation of biofilms formed by diverse human pathogens wit…
Pemphigus foliaceus (PF) is a multifactorial skin disease. Substantial evidence for microbiota dysbiosis in skin disorders was gradually revealed. In PF patients' skin lesions, we characterized the profile of microbial communities and the expression…
The liver fluke Opisthorchis viverrini causes chronic infections in humans and animals. This helminth is known to coexist with the bacterial microbiome in the host's bile duct, and their interaction potentially impacts the helminth's pathogenicity. W…
We aimed to clarify antimicrobial component (AMC) dynamics during the dry period in dairy cows and determine the impacts of varying somatic cell count (SCC) at the onset of the dry period on the subsequent changes in AMC concentrations in milk. Milk…
Implant-associated infections pose significant challenges due to bacterial resistance to antibiotics. Recent research highlights the potential of immobilizing antimicrobial peptides (AMPs) onto implants as an alternative to conventional antibiotics f…
The escalating threat of antibiotic resistance demands novel antimicrobial strategies. This study introduces PCR12mod6, a rationally designed peptide derived from the amphibiancathelicidin-HR, engineered for both antimicrobial and antioxidant functio…
This study aims to evaluate the therapeutic efficacy and potential underlying mechanisms of a novel high-power low-temperature plasma (hLTP) therapy for treatment of psoriasis. Imiquimod (IMQ)-induced rat psoriasis model was used to evaluate the ther…
Wound healing is a dynamic process involving distinct phases that are regulated by cellular and molecular interactions. This review explores the fundamental mechanisms involved in wound healing, including the roles of cytokines and growth factors wit…
LL-37 is the sole member of the cathelicidin family of antimicrobial peptides in humans, primarily produced by phagocytic leukocytes and epithelial cells, mediating a wide range of biological responses. Discovered in human neutrophils, LL-37 is known…
INTRODUCTION: The emergence of antibiotic-resistant pathogens is a significant global health concern that necessitates the development of new antimicrobial drugs. Due to its broad-spectrum action against bacteria, fungi, and viruses, human cathelicid…
BACKGROUND The study examined and compared the significance of sociodemographic, oral health behavior, and maternal factors, as well as salivary pH and salivary levels of human neutrophil peptide 1 (HNP-1), human b defensin 2 (hBD-2), and human cathe…
This paper strove to characterize and compare ejaculates collected from two geese breeds over the period of two years in the context of selected traditional, biochemical, oxidative, bacteriological, and immunological properties. Slovak white and Such…
Marijuana, an emerging risk factor for periodontitis, contains multiple potent antibacterials, particularly the phytocannabinoids. Microbial dysbiosis is a hallmark of this destructive oral disease. We examined a panel of oral bacteria for susceptibi…
Ultraviolet (UV) radiation-induced skin photoaging impacts both appearance and skin health, potentially leading to disorders and cancer. Unlike traditional sunscreens, natural antioxidants can target photoaging at its source. Among these, cathelicidi…
Rosacea is a common chronic inflammatory skin disease that predominantly affects the central face. It can impair appearance and cause various discomforts, thus negatively impacting patients' physical and mental well-being as well as their quality of…