The only human cathelicidin antimicrobial peptide, playing key roles in innate immune defense, wound healing, and modulation of inflammatory responses.
Cathelicidin LL-37, an antimicrobial peptide (AMP) of the innate immune system, wards off bacterial infections. Recent research has identified plenty of biological functions of AMPs beyond their antimicrobial activity, including antioxidant, self-ren…
Poultry are susceptible to oxidative stress, which decreases immune function and negatively affects production performance under highly intensive feeding conditions. Moreover, anthocyanins can alleviate oxidative stress and improve immune functions i…
BACKGROUND AND AIMS: Vitamin D deficiency, widely prevalent in patients with chronic kidney disease (CKD) could play a role in the pathogenesis of cardiovascular disease (CVD) by causing alterations in endothelial and immune function. We investigated…
Infections with the protozoancause abortion in cattle, likely due to the parasite's replication and excessive inflammation in the placenta. Cathelicidins are host defense peptides known for their antimicrobial and immunomodulatory functions, but thei…
Ferroptosis is an important cause of cardiomyocyte loss and cardiac dysfunction. Cathelicidin-related antimicrobial peptide (CRAMP) is an endogenous polypeptide that regulates oxidative stress in the body and is involved in ferroptosis. However, its…
OBJECTIVE: To assess the feasibility of gene expression profiling of platelets in dogs with sepsis. METHODS: This was a prospective observational feasibility study conducted at a university veterinary teaching hospital. All study dogs had CBCs and se…
OBJECTIVE AND DESIGN: We aimed to investigate potential lymphatic vessel abnormalities associated with rosacea and elucidate effective rosacea treatment mechanism using long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser (LPND). MATERIAL OR…
BACKGROUND: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disorder characterised by the formation of non-caseating granulomas in breast tissue, primarily affecting young women of childbearing age. The aetiology of IGM remains uncl…
Psoriasis, a chronic inflammatory skin disorder, is characterized by a complex interplay among immune cells. Although the specific mechanisms of platelet involvement in psoriasis are not fully elucidated, platelet activation is considered a major pat…
INTRODUCTION: The emergence of antibiotic-resistant pathogens is a significant global health concern that necessitates the development of new antimicrobial drugs. Due to its broad-spectrum action against bacteria, fungi, and viruses, human cathelicid…
Wound healing is a dynamic process involving distinct phases that are regulated by cellular and molecular interactions. This review explores the fundamental mechanisms involved in wound healing, including the roles of cytokines and growth factors wit…
While cationic antimicrobial peptides (AMPs) are extensively studied for antitumor effects, anionic AMPs remain underexplored. Notably, no amphibian-derived anionic cathelicidins with antitumor activity have been reported. This study identifies Boma-…
: Excessive body fatness is the basis of many diseases, especially civilization-related ones. The aim of this study is to analyze the body composition and serum levels of selected antimicrobial peptides (AMPs) in patients with basal cell carcinoma (B…
Bergeyella cardium causes infections in human organs. However, the mechanism of the virulence of B. cardium is unclear. Peptidases are important virulence factors in bacterial pathogens. Here, we identified three KP-43 subfamily peptidases, SpBcA, Sp…
BACKGROUND: Numerous studies have shown the presence of multiple defence factors in placental tissue, although their role is partially understood; therefore, the aim of this study was to evaluate the expression of nuclear factor-kappa B (NF-κB); huma…
BACKGROUND: Sputum extracellular DNA (eDNA) is associated with disease severity in asthma and COPD and therefore emerging as a potential therapeutic target. The aim of this study was to investigate the effect of 10 days of recombinant human DNase (rh…
species are often the cause of implant-related infections, posing a significant clinical challenge in orthopedics. Antimicrobial peptides (AMPs) like LL-37-derived FK-16 and GF-17 offer promising alternatives to conventional antibiotics; however, the…
BACKGROUND: The role of vitamin D in Coronavirus Disease 2019 (COVID-19) outcomes remains debated, but emerging evidence suggests it may enhance recovery by strengthening immune responses. Vitamin D upregulates LL-37, an antimicrobial peptide with br…
BACKGROUND The study examined and compared the significance of sociodemographic, oral health behavior, and maternal factors, as well as salivary pH and salivary levels of human neutrophil peptide 1 (HNP-1), human b defensin 2 (hBD-2), and human cathe…
BACKGROUND: Functional dermatological bases can contribute more than just delivery-they may actively modulate cutaneous homeostasis. Cleoderm™ is a dermofunctional base containing a patentedextract, palmitoyl tripeptide-8, bisabolol, hyaluronic acid,…