Antiparasitic effect of peptoids against.

Microbiology (Reading, England)2025PMID: 41082282

View on PubMed DOI: 10.1099/mic.0.001607

Plain Language Summary

Screened 14 synthetic peptoids against Cryptosporidium, identifying TM9 and TM19 as potent anti-cryptosporidial agents with minimal host toxicity. These cathelicidin-mimicking peptidomimetics offer a potential therapeutic approach for cryptosporidiosis in immunocompromised individuals and children.

Abstract

Cryptosporidiosis, caused by, poses significant health risks, particularly for children and immunocompromised individuals. Current treatments are ineffective in these vulnerable groups. This study explores the antiparasitic effects of peptoids against. Out of 14 synthetic peptidomimetics (peptoids) screened, TM9 and TM19 exhibited potent anti-cryptosporidial activity with minimal host toxicity. These findings suggest that peptoids could be a promising new therapeutic avenue for cryptosporidiosis, warranting further investigation.

Authors

Lamont, Bridget; Russell, Bruce Malcolm; Suwanarusk, Rossarin; Nielsen, Josefine Eilsø; Sørensen, Kristian; Yung, Deborah; Barron, Annelise E; Pletzer, Daniel; Muhsin-Sharafaldine, Morad-Remy

Keywords

Cryptosporidium parvumantiparasiticscathelicidin LL-37peptoids