Functional Connectomic Approach to Studying Selank and Semax Effects.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2020PMID: 32342318

View on PubMed DOI: 10.1134/S001249662001007X

Selank Semax

Plain Language Summary

A human fMRI study measuring brain functional connectivity after Selank and Semax administration in 52 healthy volunteers. Using resting-state fMRI, found that Selank modified connectivity between the right amygdala and temporal/parahippocampal regions involved in emotional processing—consistent with its anxiolytic profile. Provides the first brain imaging evidence for Selank's site of action in humans.

Abstract

The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants. The ROIs included amygdala (one of the key regions for the regulation of anxiety) and dorsolateral prefrontal cortex (DLPFC; the key region for executive functions, including working memory) in the right and left hemisphere. Resting-state fMRI was carried out three times, namely before, after 5 and 20 min of the injection of either Semax, or Selank, or placebo. Between-group alongwith between-condition differences were revealed in FC between the right amygdala and a region in fusiform, inferior and middle temporal as well as parahippocampal gyri in the right hemisphere. Post hoc analysis allowed us to define both general and specific effects of Selank and Semax on FC between the right amygdala and the right temporal cortex for the first time.

Authors

Panikratova, Ya R; Lebedeva, I S; Sokolov, O Yu; Rumshiskaya, A D; Kupriyanov, D A; Kost, N V; Myasoedov, N F

Keywords

SelankSemaxfunctional connectivity analysisresting-state fMRI