Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography.

Bulletin of experimental biology and medicine2017PMID: 29181670

View on PubMed DOI: 10.1007/s10517-017-3950-4

Plain Language Summary

Uses thromboelastography (a whole-blood clotting test) to measure anticoagulant effects of three glyproline peptides including Selank. All three showed anticoagulant properties in vitro at various concentrations, with Selank demonstrating the strongest anticoagulation effect. Unexpected finding with potential relevance for cardiovascular effects and safety considerations at high doses.

Abstract

Thromboelastography revealed anticoagulant effects of 3 glyproline oligopeptides (in various concentrations): His-Phe-Arg-Trp-Pro-Gly-Pro, Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), and Pro-Gly-Pro. The parameters R, K, MA, S, TMA, and J changed to hypocoagulation direction in comparison to the control. At this, Selank demonstrated the maximal anticoagulation potency.

Authors

Rogozinskaya, E Ya; Lyapina, M G

Keywords

anticoagulation activityregulatory peptidesthromboelastography