Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny.

Bulletin of experimental biology and medicine2007PMID: 18683497

Animal StudySelank

Plain Language Summary

Tests Selank in adult rats whose dopamine/noradrenaline systems were damaged in early life by neonatal 6-OHDA treatment. Selank (300 μg/kg) restored learning, memory, and sensory attention impaired by this early-life catecholamine depletion. Demonstrates neuroprotective and cognitive-restoring effects relevant to developmental brain injuries.

Abstract

Effects of selank on learning, memory, and attention to sensory stimuli of different modality were studied in adult Wistar rats treated with 6-hydroxydopamine (neurotoxin selectively damaging catecholaminergic neurons and their terminals) during the first 3 days of life. Selank (300 microg/kg) restored cognitive processes disordered by chronic artificial inhibition of the cerebral catecholaminergic system.

Authors

Semenova, T P; Kozlovskaya, M M; Zakharova, N M; Kozlovskii, I I; Zuikov, A V