[Selank-induced normalizing effects on the integrative brain activity and biogenic amine level disorders due to antenatal hypoxia].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova2006PMID: 17385425

Animal StudySelank

Plain Language Summary

A companion study to PMID 18197389, further demonstrating that Selank reverses neurodevelopmental deficits from prenatal hypoxia. Confirms that Selank (300 μg/kg) significantly improves sensory attention (2–3x), learning capacity (1.5x), and normalizes serotonergic/noradrenergic brain balance in adult rats exposed to hypoxia during gestation—supporting developmental neuroprotection.

Abstract

The effects of Selank synthetic analog of Tuftsin, representing the heptapeptide forming Thr-Lys-Pro-Arg-Pro-Gly-Pro, on behavior and serotonin/noradrenalin concentrations in brain were investigated in adult rats exposed to hypoxia during 14-16 days of gestation. It was revealed that injection of Selank (300 mkg/kg, i/p) increased 2--3-fold (p < 0.01) the sensory attention, facilitated 1.5-fold the learning capacity (p < 0.01), normalized exploratory activity in the open field and hole board, and recovered the balance of serotonergic and noradrenergic brain system activity. The data obtained demonstrate the possibility of Selank to compensate for long-lasting negative effects of antenatal hypoxia on integrative brain activity and brain monoamine level.

Authors

Semenova, T P; Kozlovskaia, M M; Zuĭkov, A V; Kozlovskiĭ, I I; Zakharova, N M; Andreeva, L A