[Selank and short peptides of Taftsin derivatives in regulation of adaptive behavior of animals in stress].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova2002PMID: 12154572

Animal StudySelank

Plain Language Summary

Tests Selank and tuftsin derivatives for antistress effects across multiple mouse strains with genetically opposite stress responses. Peptides showed individual effects correlating with their molecular structure and potential degradation products. Confirms that targeted peptide synthesis can produce predictable, selective anxiolytic and adaptive behavior-enhancing effects.

Abstract

Effects of 10 peptides, tuftsin and Selank derivatives upon behavior during emotional stress induced by conflict situation, were studied in Balb/c and C57BL/6 male mice with genetically determined opposite types of emotional stress reaction, in white male mice and in Wistar male rats divided into different groups according to the type of emotional reactivity. Positive effects of some peptides upon the adaptive behavior of animals in stress situation were demonstrated. Individual physiologically important effects depending on molecular structure of the peptides under study and/or their fragments, possible products of degradation, were revealed. The results obtained confirm the perspectives of aimed synthesis of peptides with definite pharmacological activity, which are not ksenobiotics and will have no side effects.

Authors

Kozlovskaia, M M; Kozlovskiĭ, I I; Val'dman, E A; Seredenin, S B