A tripeptide (Lys-Pro-Val) derived from alpha-MSH, studied for its anti-inflammatory, wound healing, and gut protective properties.
Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers.
Science advances|2026|Cheng J et al.
Oral delivery of peptide therapeutics remains challenging due to gastrointestinal (GI) degradation and poor intestinal absorption. Here, we propose a self-immolative peptide prodrug conjugate (SIPPC) platform for inflammation-targeted oral delivery,…
Animal Study
PMID: 41533788
NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development.
Cell death and differentiation|2026|Zeng K et al.
NLRP3 functions as a critical intracellular danger sensor for inflammasome activation, playing a crucial role in autoimmune diseases. Vitiligo progression has been linked to NLRP3, yet its specific involvement in melanocytes of vitiligo remains poorl…
Animal Study
PMID: 40935835
A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.
The Journal of sports medicine and physical fitness|2026|Coutinho L, DE Oliveira Neves L, Camilo R
The pursuit of pharmacological enhancement in sport has evolved from the widespread use of anabolic-androgenic steroids (AAS) to novel agents such as peptides and peptide analogues. Marketed as more selective and ostensibly safer alternatives, peptid…
PMID: 41880199
Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review.
International journal of medical sciences|2025|Adnan S et al.
Wound healing is a complex and dynamic process that requires the coordination of cellular, molecular, and physiological events to restore tissue integrity. Despite notable advances in treatment strategies, optimizing healing outcomes, particularly in…
Review
PMID: 41209547
Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease.
Drug discovery today|2025|Rodrigues J et al.
Inflammatory bowel diseases (IBDs) are chronic disorders affecting the gastrointestinal tract, causing severe inflammation and tissue damage. Current treatments often have adverse effects, underscoring the need for alternatives. This article is a sho…
Review
PMID: 41241376
Multicompartmental Hydrogel Microspheres with a Concentric Thin Oil Layer: Protecting and Targeting Therapeutic Agents for Inflammatory Bowel Disease.
ACS applied bio materials|2025|Jeong H et al.
Although oral delivery of therapeutic agents offers numerous benefits, its application is limited due to the digestive tract's harsh conditions (e.g., strong acidity and high osmolarity), which impair activity and create challenges in achieving targe…
PMID: 40030207
Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway.
Tissue & cell|2025|Sung J et al.
Airborne particulate matter (PM) poses a major environmental risk that impairs skin health by triggering oxidative stress, inflammation, and cell death. In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenou…
PMID: 40073467
Non-contrast-enhanced magnetic resonance urography for measuring split kidney function in pediatric patients with hydronephrosis: comparison with renal scintigraphy.
Pediatric nephrology (Berlin, Germany)|2024|He K et al.
BACKGROUND: Split kidney function (SKF) is critical for treatment decision in pediatric patients with hydronephrosis and is commonly measured using renal scintigraphy (RS). Non-contrast-enhanced magnetic resonance urography (NCE-MRU) is increasingly…
PMID: 38041747
KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy.
Advanced healthcare materials|2024|Zhang L et al.
Cardiovascular disease (CVD) is a leading cause of death globally, and vascular calcification (VC) is an important independent risk factor for predicting CVD. Currently, there are no established therapeutic strategies for the treatment of VC. Althoug…
Animal StudyIn Vitro
PMID: 39252648
A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment.
Bioactive materials|2024|Marotti V et al.
Current treatments for inflammatory bowel disease (IBD) treatment consist of anti-inflammatory products. In this study, we sought to induce the physiological secretion of glucagon-like peptide 2, a peptide with intestinal growth-promoting activity, v…
PMID: 37859689
PepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combined treatment of acute and chronic DSS-induced ColitiS.
Frontiers in pharmacology|2024|Zhang D et al.
INTRODUCTION: Inflammatory bowel disease (IBD), as a chronic and recurrent inflammatory bowel diseases with limited therapeutic outcomes, is characterized by immune disorders and intestinal barrier dysfunction. Currently, the most medications used to…
Animal Study
PMID: 39211778
Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers.
ACS applied materials & interfaces|2024|Li D et al.
The pathogenesis of ulcerative colitis (UC) is associated with the shedding of the gut mucus. Herein, inspired by the biological functions of mucus, growth factors-loaded in situ hydrogel (PHE-EK) was designed for UC treatment by integrating dihydroc…
Animal StudyIn Vitro
PMID: 38289234
Vimentin is required for tumor progression and metastasis in a mouse model of non-small cell lung cancer.
Oncogene|2023|Berr A et al.
Vimentin is highly expressed in metastatic cancers, and its expression correlates with poor patient prognoses. However, no causal in vivo studies linking vimentin and non-small cell lung cancer (NSCLC) progression existed until now. We use three comp…
Animal Study
PMID: 37161053
Isolation, virtual screening, action mechanisms, chelation with zinc ions, and stability of ACE-inhibitory peptides from ginkgo seed globulin.
RSC advances|2023|Gao W, Liu M, Wang Y
Ginkgo seed has potential applications in the prevention and treatment of hypertension, but its application in food is limited. Thus, ginkgo seed globulin was hydrolyzed using dual enzymes (Alcalase and thermolysin). After gel column separation, reve…
PMID: 37860176
The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials.
Cells|2023|Gravina A et al.
The melanocortin system is a complex set of molecular mediators and receptors involved in many physiological and homeostatic processes. These include the regulation of melanogenesis, steroidogenesis, neuromodulation and the modulation of inflammatory…
ReviewAnimal Study
PMID: 37508552
Skin-adaptive film dressing with smart-release of growth factors accelerated diabetic wound healing.
International journal of biological macromolecules|2022|Zhao Y et al.
The general treatment of diabetic wound was use of wound dressings to absorb excess exudate. However, traditional wound dressings neither mimic the skin-like properties nor easily be withdrawn from the wound. Herein, the skin-adaptive three-layered f…
Animal Study
PMID: 36240893
Mitigating the toxicity of palmitoylated analogue of α-melanocyte stimulating hormone(11-13) by conjugation with gold nanoparticle: characterisation and antibacterial efficacy against methicillin sensitive and resistant Staphylococccus aureus.
World journal of microbiology & biotechnology|2022|Mitra S, Mondal A, Mukhopadhyay K
In an attempt to develop potent and non-toxic antimicrobial agent, the palmitoylated analogue of α-melanocyte stimulating hormone(11-13), Pal-α-MSH(11-13) was conjugated with gold nanoparticles (GNPs) for the first time and the efficacy of derived co…
Animal Study
PMID: 35972627
A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon.
Acta biomaterialia|2022|Zhao Y et al.
Ulcerative colitis (UC) usually occurs in the superficial mucosa of the colorectum. Here, a double-network hydrogel (PMSP) was constructed from maleimided γ-polyglutamic acid and thiolated γ-polyglutamic acid through crosslinking of thiol-maleimide a…
Animal Study
PMID: 35245681
Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats.
ACS biomaterials science & engineering|2021|Sun J et al.
KPV (Lys-Pro-Val), which is a tripeptide derived from α-MSH (α-melanocyte-stimulating hormone), has an anti-inflammatory effect on colitis. However, KPV solution is very unstable when rectally administered, compromising its therapeutic efficacy. Here…
Animal Study
PMID: 34547895
Biomimetic Melanosomes Promote Orientation-Selective Delivery and Melanocyte Pigmentation in the HO-Induced Vitiligo Mouse Model.
ACS nano|2021|Sun M et al.
Extremely limited drug retention and depigmentation represent the greatest barriers against vitiligo treatment advancement. Here, inspired by biological melanosomes, the primary melanin transporter, we developed biomimetic melanosomes to combat react…
Animal Study
PMID: 34662120