A tripeptide (Lys-Pro-Val) derived from alpha-MSH, studied for its anti-inflammatory, wound healing, and gut protective properties.
NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development.
Cell death and differentiation|2026|Zeng K et al.
NLRP3 functions as a critical intracellular danger sensor for inflammasome activation, playing a crucial role in autoimmune diseases. Vitiligo progression has been linked to NLRP3, yet its specific involvement in melanocytes of vitiligo remains poorl…
Animal Study
PMID: 40935835
Methodologies for developing and applying consensus-based recommendations in epilepsy care: A narrative review.
Epilepsia|2026|Haffner R et al.
Consensus-based recommendations (CBRs) are essential for health care decision-making when evidence is limited or conflicting. They can be developed using established methodologies such as the Delphi technique, the nominal group technique (NGT), and t…
Review
PMID: 41396016
Application of AI for the functional elucidation of rice associated microbial community for the improved productivity.
3 Biotech|2026|Joyce J et al.
UNLABELLED: Rice microbiome plays a critical role in the growth, health, stress tolerance, nutrient uptake, root development, and productivity of its host. In this study, advanced machine learning algorithms were applied to analyze the genomic data f…
PMID: 41502473
Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers.
Science advances|2026|Cheng J et al.
Oral delivery of peptide therapeutics remains challenging due to gastrointestinal (GI) degradation and poor intestinal absorption. Here, we propose a self-immolative peptide prodrug conjugate (SIPPC) platform for inflammation-targeted oral delivery,…
Animal Study
PMID: 41533788
Diagnostic Yield and Safety of Medical Thoracoscopic Biopsy in Undiagnosed Exudative Pleural Effusion: A Five-Year Retrospective Study From a Tertiary Care Center in South India.
Cureus|2026|Kallarakal J, K P V
BACKGROUND: Medical thoracoscopy is a minimally invasive procedure with high diagnostic yield in undiagnosed exudative pleural effusions. There is limited data on its efficacy and safety from high-volume tertiary centers in India, considering the cha…
PMID: 41769616
A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.
The Journal of sports medicine and physical fitness|2026|Coutinho L, DE Oliveira Neves L, Camilo R
The pursuit of pharmacological enhancement in sport has evolved from the widespread use of anabolic-androgenic steroids (AAS) to novel agents such as peptides and peptide analogues. Marketed as more selective and ostensibly safer alternatives, peptid…
PMID: 41880199
Multicompartmental Hydrogel Microspheres with a Concentric Thin Oil Layer: Protecting and Targeting Therapeutic Agents for Inflammatory Bowel Disease.
ACS applied bio materials|2025|Jeong H et al.
Although oral delivery of therapeutic agents offers numerous benefits, its application is limited due to the digestive tract's harsh conditions (e.g., strong acidity and high osmolarity), which impair activity and create challenges in achieving targe…
PMID: 40030207
Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway.
Tissue & cell|2025|Sung J et al.
Airborne particulate matter (PM) poses a major environmental risk that impairs skin health by triggering oxidative stress, inflammation, and cell death. In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenou…
PMID: 40073467
Clinical efficacy and safety of two highly purified human menopausal gonadotropins in women undergoing in vitro fertilization.
Reproduction & fertility|2025|Rao K et al.
ABSTRACT: This study compared the efficacy and safety of two highly purified (HP) human menopausal gonadotropin (hMG) preparations, Gynogen HP and Menopur, in women undergoing controlled ovarian stimulation (COS) for in vitro fertilization (IVF). A m…
Randomized Controlled TrialIn Vitro
PMID: 40445794
Enhanced magnetic properties through tailoring of morphology of electrospun strontium hexaferrite nanofibers.
Scientific reports|2025|Vats N et al.
This work reports a simple yet unique way of tailoring the morphology of M-type Strontium Hexaferrite, SrFeO(SFO) particles inside the nanofibers. The reported materials were synthesized by the polymer-sol-assisted electrospinning technique followed…
PMID: 40603893
Digital neonatal neurocritical care in Brazil: a retrospective multicentre cohort study of over 11,000 remotely monitored infants.
Lancet regional health. Americas|2025|Variane G et al.
BACKGROUND: Neonatal brain injury is a major global health challenge, disproportionately affecting low- and middle-income countries (LMIC), where access to specialized care remains limited. Technology-driven neuroprotective strategies may allow the d…
PMID: 41035815
Challenges in clinical nutrition research in Latin America: A narrative review.
Clinical nutrition ESPEN|2025|Correia M, Papapietro K, Fuchs-Tarlovsky V
Conducting high-quality clinical research requires collaborative, interdisciplinary efforts, sustained institutional leadership, and adequate financial support - resources that are unfortunately insufficient across much of Latin America. This situati…
Review
PMID: 41176232
Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review.
International journal of medical sciences|2025|Adnan S et al.
Wound healing is a complex and dynamic process that requires the coordination of cellular, molecular, and physiological events to restore tissue integrity. Despite notable advances in treatment strategies, optimizing healing outcomes, particularly in…
Review
PMID: 41209547
Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease.
Drug discovery today|2025|Rodrigues J et al.
Inflammatory bowel diseases (IBDs) are chronic disorders affecting the gastrointestinal tract, causing severe inflammation and tissue damage. Current treatments often have adverse effects, underscoring the need for alternatives. This article is a sho…
Review
PMID: 41241376
A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment.
Bioactive materials|2024|Marotti V et al.
Current treatments for inflammatory bowel disease (IBD) treatment consist of anti-inflammatory products. In this study, we sought to induce the physiological secretion of glucagon-like peptide 2, a peptide with intestinal growth-promoting activity, v…
PMID: 37859689
Non-contrast-enhanced magnetic resonance urography for measuring split kidney function in pediatric patients with hydronephrosis: comparison with renal scintigraphy.
Pediatric nephrology (Berlin, Germany)|2024|He K et al.
BACKGROUND: Split kidney function (SKF) is critical for treatment decision in pediatric patients with hydronephrosis and is commonly measured using renal scintigraphy (RS). Non-contrast-enhanced magnetic resonance urography (NCE-MRU) is increasingly…
PMID: 38041747
Growth Factors-Loaded Temperature-Sensitive Hydrogel as Biomimetic Mucus Attenuated Murine Ulcerative Colitis via Repairing the Mucosal Barriers.
ACS applied materials & interfaces|2024|Li D et al.
The pathogenesis of ulcerative colitis (UC) is associated with the shedding of the gut mucus. Herein, inspired by the biological functions of mucus, growth factors-loaded in situ hydrogel (PHE-EK) was designed for UC treatment by integrating dihydroc…
Animal StudyIn Vitro
PMID: 38289234
Learnings from the first AI-enabled skin cancer device for primary care authorized by FDA.
NPJ digital medicine|2024|Venkatesh K, Kadakia K, Gilbert S
The U.S. Food and Drug Administration’s (FDA) recent authorization of DermaSensor, an AI-enabled device for skin cancer detection in primary care, marks a pivotal moment in digital health innovation. Clinically, the authorization of the first AI-enab…
PMID: 38879640
PepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combined treatment of acute and chronic DSS-induced ColitiS.
Frontiers in pharmacology|2024|Zhang D et al.
INTRODUCTION: Inflammatory bowel disease (IBD), as a chronic and recurrent inflammatory bowel diseases with limited therapeutic outcomes, is characterized by immune disorders and intestinal barrier dysfunction. Currently, the most medications used to…
Animal Study
PMID: 39211778
Amivantamab efficacy in wild-type EGFR NSCLC tumors correlates with levels of ligand expression.
NPJ precision oncology|2024|Rivera-Soto R et al.
Amivantamab is an FDA-approved bispecific antibody targeting EGF and Met receptors, with clinical activity against EGFR mutant non-small cell lung cancer (NSCLC). Amivantamab efficacy has been demonstrated to be linked to three mechanisms of action (…
PMID: 39242834