Histamine release on rat pleural and peritoneal mast cells elicited by human GRF(1-29)NH2.

International archives of allergy and immunology1993PMID: 7679022

Plain Language Summary

Human GHRH was found to trigger histamine release from mast cells in rat pleural and peritoneal tissues. The release was temperature-dependent (optimal at 37 degrees Celsius) and could be blocked by a metabolic inhibitor, suggesting it involves active cellular processes rather than simple membrane disruption.

Abstract

We have studied the release of histamine elicited by human GRF(1-29)NH2 on rat peritoneal and pleural mast cells. The secretion is temperature dependent, the release being optimal at 37 degrees C, and it can be inhibited with antimycin A. The activation of pleural and peritoneal mast cells is similar, but there is a slight inhibition for both populations after purification with Percoll.

Authors

Estévez, M D; Botana, M A; Arnáez, E; Vieytes, M R; Botana, L M