[Effect of polypeptide factors of the thymus, pineal gland, bone marrow and anterior hypothalamus on the realization of transplacental carcinogenesis].

Eksperimental'naia onkologiia1984PMID: 6548961

Animal StudyEpitalon

Plain Language Summary

Pineal gland polypeptide factor (epithalamin) and thymus factor both reduced tumor incidence and multiplicity in rats exposed to a transplacental carcinogen, while also prolonging the time before tumors appeared. The protective effect was particularly strong against tumors of the spinal cord, kidneys, and peripheral nervous system, likely due to normalization of hormonal, metabolic, and immunological disruptions caused by the carcinogen.

Abstract

The postnatal action of low-molecular polypeptide factors of thymus (FT), pineal gland (FP), bone marrow (FRM) and anterior hypothalamus (FAH) on transplacental carcinogenic effect of N-nitroso-N-ethylurea in rats was studied. Both FT and FP administrations decreased incidence and multiplicity of tumours and prolonged their mean latent periods. These drugs inhibited mainly the development of tumours of the spinal cord, kidneys and peripheral nervous system but not those of the brain. Both FBM and FAH had no significant influence on transplacental carcinogenesis. FT and FP anticarcinogenic effect is supposed to be due to their normalizing action on hormonal metabolic and immunological shifts arising in the body after transplacental administration of the carcinogen.

Authors

Bespalov, V G; Aleksandrov, V A; Anisimov, V N; Morozov, V G; Khavinson, V Kh