Loss of lean mass is a potential concern for semaglutide-induced weight loss. This study indicates that semaglutide has unexpected effects on skeletal muscle mass and strength in mice, demonstrating a need to more carefully assess these effects in humans.
Authors
Karasawa, Takuya; Choi, Ran Hee; Meza, Cesar A; Rout, Subhasmita; Drummond, Micah J; Chaix, Amandine; Funai, Katsuhiko