Botulinum toxin, as a common facial wrinkle removal product, can be used for facial rejuvenation or improvement of skin texture, which is a commonly used cosmetic injectable product. However, botulinum toxin may lead to decreased immune function, causing a series of subsequent complications. This case report describes a 32-year-old female patient who developed herpes zoster after receiving injections of semaglutide, botulinum toxin, and hyaluronic acid. Viral infection and decreased immune function are common triggers of herpes zoster. After injection of botulinum toxin, the local immune response may be affected, which may activate the latent varicella-zoster virus or lead to decreased immune function that causes herpes zoster.