Role of MOTS-c in the regulation of bone metabolism.

Frontiers in physiology2023PMID: 37200834

View on PubMed DOI: 10.3389/fphys.2023.1149120

Plain Language Summary

Review of MOTS-c's role in bone metabolism, covering its effects on promoting osteoblast proliferation, differentiation, and mineralization while inhibiting osteoclast formation, the exercise-mediated upregulation of MOTS-c as a bone-protective mechanism, and the potential for MOTS-c supplementation to prevent osteoporosis and promote bone healing. Synthesizes the skeletal biology of MOTS-c. Establishes MOTS-c as a bone-anabolic mitochondrial peptide—providing a mechanistic framework for exercise-mediated skeletal protection and positioning MOTS-c as a candidate osteoporosis preventive therapy that simultaneously promotes bone formation and inhibits resorption.

Abstract

MOTS-c, a mitochondrial-derived peptide (MDP), is an essential regulatory mediator of cell protection and energy metabolism and is involved in the development of specific diseases. Recent studies have revealed that MOTS-c promotes osteoblast proliferation, differentiation, and mineralization. Furthermore, it inhibits osteoclast production and mediates the regulation of bone metabolism and bone remodeling. Exercise effectively upregulates the expression of MOTS-c, but the specific mechanism of MOTS-c regulation in bone by exercise remains unclear. Therefore, this article reviewed the distribution and function of MOTS-c in the tissue, discussed the latest research developments in the regulation of osteoblasts and osteoclasts, and proposed potential molecular mechanisms for the effect of exercise on the regulation of bone metabolism. This review provides a theoretical reference for establishing methods to prevent and treat skeletal metabolic diseases.

Authors

Yi, Xuejie; Hu, Guangxuan; Yang, Yang; Li, Jing; Jin, Junjie; Chang, Bo

Keywords

MOTS-cbonemetabolismmovement presentationosteoblastosteoclast