[Effects of exercise intervention on mitochondrial-derived peptide MOTS-c in the germ cells of obese men].

Zhonghua nan ke xue = National journal of andrology2021PMID: 34914298

Plain Language Summary

Review and research article examining the effect of exercise intervention on MOTS-c levels specifically in germ cells of obese men, addressing how obesity reduces circulating MOTS-c in males and how exercise-induced MOTS-c restoration in spermatogenic cells may improve male reproductive dysfunction associated with obesity. Connects exercise, MOTS-c, and male fertility in the context of obesity. Identifies exercise-induced MOTS-c restoration in male germ cells as a mechanism linking physical activity to improved fertility in obese men—providing a novel reproductive biology rationale for exercise in male obesity-related infertility beyond general metabolic improvement.

Abstract

Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) is a newly discovered mitochondrial-derived peptide with the main functions of promoting glucose metabolism and reducing adipose tissue. MOTS-c was found to be a substance that can mimic the motor effect and improve the motor ability. It is sex-related and the circulating MOTS-c level is decreased in obese males. Obesity can cause male reproductive dysfunction, while exercise can improve obesity-induced reduction of male reproductive function. This article discusses the effect of exercise intervention on the mitochondrial-derived peptide MOTS-c in the germ cells of obese men.

Authors

Li, Yi-Ran; Kang, Mei-Si; Yi, Xue-Jie

Keywords

MOTS-cmalemitochondrial-derived peptideobesityreproductionsports