Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH-PGP (Semax).

Bulletin of experimental biology and medicine2021PMID: 33459919

View on PubMed DOI: 10.1007/s10517-021-05072-z

Animal StudySemax

Plain Language Summary

Semax was tested for its effect on the colon during stress in rats subjected to physical restraint. Stressed animals developed inflammation and structural damage in the colon wall along with elevated stress hormones, while Semax administration reduced corticosterone levels and protected the colon from these changes. The findings suggest Semax has protective effects on gut health during stress, likely through a combination of central brain effects and direct action on receptors in the intestine.

Abstract

We studied the effect of intraperitoneal administration ACTH-PGP in doses of 5, 50, 150, and 450 μg/kg to Wistar male rats 12-15 min before modeling restraint stress on the morphofunctional state of the colon. In rats exposed to restraint stress, signs of atrophy and inflammatory reaction in the colon wall, changes in functional activity and number of mast cells, and increased serum level of corticosterone were observed. Administration of the peptide led to a decrease in corticosterone concentration, alleviated stress-induced pathomorphological changes, and promoted adaptation of the intestinal wall to stress. The positive effects of ACTH-PGP can be determined by multifunctional nature of the physiological and pharmacological effects of the neuropeptide.

Authors

Svishcheva, M V; Mishina, Ye S; Medvedeva, O A; Bobyntsev, I I; Mukhina, A Y; Kalutskii, P V; Andreeva, L A; Myasoedov, N F

Keywords

Semaxcoloncorticosteronerestraint stress