[AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.].

Advances in gerontology = Uspekhi gerontologii2020PMID: 33280326

Plain Language Summary

Epitalon was found to restore circadian rhythm gene expression in people with reduced pineal gland function, a condition common in night shift workers. The peptide normalized overactive Clock and Csnk1e genes and boosted underactive Cry2 gene expression, while increasing melatonin metabolite levels by 1.7 times in middle-aged individuals.

Abstract

Night work provides biorhythms desynchronization, disorder of melatonin-producing function and accelerated pineal gland aging. One of the promising geroprotectors restoring the pineal melatonin synthesis is the AEDG (Ala-Glu-Asp-Gly) peptide. AEDG peptide increases in 1,7 times the 6-sulfatoxymelatonin (6-SOMT) excretion in the urine of middle-aged people. Moreover, AEDG peptide normalized circadian Clock and Csnk1e genes hyper expression in leukocytes in 1,9-2,1 times and increases the Cry2 gene hypo expression in peripheral blood lymphocytes in 2 times in people with reduced melatonin-producing epiphysis function. The geroprotective effect of the AEDG peptide is based on its ability to restore the epiphysis melatonin-producing function by means regulation of human circadian genes expression.

Authors

Ivko, O M; Linkova, N S; Ilina, A R; Sharova, A A; Ryzhak, G A

Keywords

AEDG peptideaccelerated agingcircadian genesmelatoninpineal gland