This article reports that thymosin alpha-1 does not correct the F508del-CFTR protein defect that causes cystic fibrosis in airway cells. The finding adds to the scientific debate about whether thymosin alpha-1 can serve as a therapeutic agent for the underlying molecular defect in CF.
Tomati, Valeria; Caci, Emanuela; Ferrera, Loretta; Pesce, Emanuela; Sondo, Elvira; Cholon, Deborah M; Quinney, Nancy L; Boyles, Susan E; Armirotti, Andrea; Ravazzolo, Roberto; Galietta, Luis Jv; Gentzsch, Martina; Pedemonte, Nicoletta