The polypeptide complex Pineamin increased nighttime melatonin metabolite excretion by 1.9 times in elderly patients with diminished pineal gland function, an effect similar to that previously observed with Epithalamin. Both Pineamin and Epithalamin restore melatonin levels during aging, confirming their stimulatory effect on pineal melatonin synthesis.
Trofimova, S V; Linkova, N S; Klimenko, A A; Kvetnaia, T V; Khavinson, V Kh