Influence of ACTG-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress.

Bulletin of experimental biology and medicine2017PMID: 28577097

View on PubMed DOI: 10.1007/s10517-017-3748-4

Animal StudySemax

Plain Language Summary

Semax protected liver cells from stress-induced damage in rats subjected to chronic emotional and pain stress. It normalized liver protein production and reduced elevated liver enzyme levels in the blood, with the protective effect becoming stronger at higher doses. The findings point to Semax's utility not just as a neuroprotective agent but also as a stress-limiting drug that shields organs outside the brain.

Abstract

We studied the effect of intraperitoneal administration of peptide ACTG-PGP to male Wistar rats in doses of 5, 50, 150, and 450 μg/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress. A dose-dependent stress-limiting effect of the peptide was observed: it normalized the protein synthesis function of the liver and serum activity of ALT. The anticytolytic effect of the peptide increased with increasing its dose against the background of the increase in the relative number of multinucleated and multinucleolated cells and deceleration of the recovery of serum protein concentration. The decrease of hepatocyte cytolysis against the background of more intense morphological signs of protein synthesis processes attests to activation of reparative processes in the liver parenchyma via enhanced constitutional synthesis of protein.

Authors

Ivanov, A V; Bobyntsev, I I; Shepeleva, O M; Kryukov, A A; Andreeva, L A; Myasoedov, N F

Keywords

ACTG4-7-PGP (Semax)aminotransferasedegeneration of the liveremotional and painful stressliver