[Adhesion molecule JAM-A, its function and mechanism of epigenetic regulation].

Advances in gerontology = Uspekhi gerontologii2015PMID: 28509452

Plain Language Summary

Epitalon (Ala-Glu-Asp-Gly) and related short peptides may influence the expression of the F11R gene encoding JAM-A, an adhesion molecule involved in tight junction formation and immune function. JAM-A plays a role in age-related diseases including atherosclerosis, stroke, thrombosis, and hypertension, suggesting these peptides could help restore JAM-A synthesis in aging cells.

Abstract

The article represents evidence about structures, properties and functions of adhesion molecule JAM-A/1 belonging to JAM subfamily. This protein plays an important role in epithelial tight junction formation and immune function. Current article focuses on the role of JAM-A protein in pathogenesis associated to ageing: atherosclerosis, apoplexy, thrombosis, hypertension, ophthalmological pathology. We propose short peptides Lys-Glu, Lys-Glu-Asp, and Ala-Glu-Asp-Gly could influence on F11R gene expression that leads to recovery of JAM-A synthesis in cells.

Authors

Kuznik, B I; Khavinson, V Kh; Tarnovskaya, S I; Linkova, N S; Kozina, L S; Dyakonov, M M

Keywords

JAM-Aage-related pathologyepigeneticsshort peptides