[Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides].

Biofizika2014PMID: 25730989

Plain Language Summary

Epitalon and kidney-specific peptides were tested for their ability to protect kidneys from injury caused by muscle breakdown (rhabdomyolysis). The peptides showed protective effects by addressing multiple injury mechanisms including toxic damage to kidney cells, oxidative stress, and energy imbalance, helping prevent acute kidney failure.

Abstract

The influence of the organospecific peptides--kidney tripeptides T-31 and T-35, pineal tetrapeptide epitalon on the main mechanisms of kidney injury caused by experimental rhabdomyolysis--toxic injury of tubular cells, development of oxidative stress and energetic misbalance, leading to significant disturbances of the functional state of kidneys and development of acute kidney failure was studied. The renoprotective effect of oligopeptides realized by impact on all of the indicated mechanisms of kidney injury and confirmed by correlation between them was estimated.

Authors

Zamorskiĭ, I I; Shchudrova, T S