[Influence of peptides from pineal gland on thymus function at aging].

Advances in gerontology = Uspekhi gerontologii2010PMID: 21510076

Plain Language Summary

Researchers reviewed evidence on how pineal gland peptides affect thymus function during aging. Epitalon and Epithalamin proved more effective at reversing thymus decline than thymic peptides were at protecting the pineal gland, with the key mechanism being activation of gene transcription through immune-endocrine signaling.

Abstract

The interference between thymus and pineal gland during their involution is considered in this review. The research data about influence of thymus peptides on pineal gland and pineal peptides on thymus is summarized. Analysis of these data showed that pineal peptides (epithalamin, epitalon) had more effective geroprotective effect on thymus involution in comparison with geroprotective effect of thymic peptides (thymalin, thymogen) on involution of pineal gland. The key mechanisms of pineal peptides effect on thymus dystrophy is immunoendocrine cooperation, which is realized as transcription's activation of various proteins.

Authors

Lin'kova, N S; Poliakova, V O; Trofimov, A V; Sevost'ianova, N N; Kvetnoĭ, I M