Anticoagulation and antiplatelet effects of semax under conditions of acute and chronic immobilization stress.

Bulletin of experimental biology and medicine2010PMID: 21113455

Animal StudySemax

Plain Language Summary

Under conditions of physical stress (immobilization), rats develop a tendency toward excessive blood clotting. Repeated intranasal Semax before the stress episodes activated the body's natural anticoagulation system, preventing this hypercoagulation response. The protective effect was seen with both acute and chronic stress conditions.

Abstract

The effects of semax on anticoagulant, fibrinolytic, and platelet components of the anticoagulation system were studied on albino rats under conditions of acute and chronic immobilization stress. Semax exhibited a protective antistress effect after repeated intranasal administration under conditions of hypercoagulation developing in response to immobilization stress of different degree. The effect manifested in stimulation of the anticoagulation system.

Authors

Grigorjeva, M E; Lyapina, L A