[Protective antithrombotic effects of proline-containing peptides in the animal body subjected to stress].

Izvestiia Akademii nauk. Seriia biologicheskaia2010PMID: 20799647

Animal StudySemax

Plain Language Summary

Simple proline-containing peptides - including Gly-Pro, Pro-Gly, Pro-Gly-Pro, and Semax - were each given intranasally to rats before stressful immobilization. All four peptides prevented the blood-clotting abnormalities that stress normally triggers, boosting anticoagulant and fibrinolytic activity instead. The short dipeptides showed the strongest antistress effect, but Semax also provided substantial protection against stress-induced clotting.

Abstract

We discovered that simple proline-containing peptides Gly-Pro, Pro-Gly, Pro-Gly-Pro, and semax had an antistress protective effect on the organism appearing as anticoagulation system activation. Repeated intranasal injection of each of these peptides to rats prior to acute immobilization stress prevented a hypercoagulation response to prolonged stress lasting 60 min. At the same time there was increase of antithrombotic, anticoagulant, and fibrin depolymerization activity and recovery of enzymatic fibrinolytic activity. Dipeptides were found to have the greatest antistress effect. Our results showed that semax had a protective effect against enhanced blood coagulability resulting from repeated immobilization stress.

Authors

Liapina, L A; Grigor'eva, M E; Andreeva, L A; Miasoedov, N F