[Effect of semax on heart rate variability in various daytime periods].

Eksperimental'naia i klinicheskaia farmakologiia2009PMID: 19441725

Animal StudySemax

Plain Language Summary

This study examined the effect of Semax on heart rate variability across different daytime periods. The neuropeptide modulated autonomic cardiac regulation in a time-dependent manner, suggesting circadian-dependent cardiovascular effects.

Abstract

Peptide drug semax with nootropic properties did not change the heart rate variability in rats in the morning, but produced a significant optimizing action and attenuated the stress-induced sympathetic influences on the heart in the evening. It is suggested that semax has a chronotropic activity, which may participate in realization of the specific drug action.

Authors

Arushanian, E B; Popov, A V