Hepatitis B virus genotypes: "clinical & therapeutic implications".

JPMA. The Journal of the Pakistan Medical Association2009PMID: 19260575

Plain Language Summary

This review covers the eight known genotypes of hepatitis B virus and their clinical significance, including differences in geographical distribution, disease progression, and response to antiviral therapies. Understanding genotype-specific patterns is increasingly important for guiding treatment decisions and predicting patient outcomes in chronic hepatitis B infection.

Abstract

Hepatitis B virus is a crucial public health problem in Pakistan. It has been classified into eight genotypes (A-H) based on genome sequence divergence. Hepatitis B virus genotypes have distinct geographical distributions. Recently genotypes of hepatitis B have received a lot of attention due to its clinical as well as therapeutic importance. In this review, we will discuss the epidemiology, clinical outcome and response to antiviral therapy for different hepatitis B virus genotypes.

Authors

Khawaja, Rajab Ali; Khawaja, Asad Ali