Effect of tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the structure and function of the thyroid gland in neonatally hypophysectomized chickens.

Bulletin of experimental biology and medicine2008PMID: 19024016

Plain Language Summary

The tetrapeptide Ala-Glu-Asp-Gly (Epitalon) and Lys-Glu-Asp-Gly, administered to hypophysectomized chickens for 40 days, increased concentrations of thyrotropic hormone and thyroid hormones while restoring thyroid gland structure. These results demonstrate that these short peptides can compensate for pituitary deficiency in regulating thyroid function.

Abstract

Tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly were synthesized on the basis of amino acid composition of pituitary cytomedins. Administration of these tetrapeptides to hypophysectomized chickens for 40 days was followed by an increase in the concentrations of thyrotropic hormone and thyroid hormones and recovery of thyroid gland structure.

Authors

Kuznik, B I; Pateyuk, A V; Rusaeva, N S