Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex.

Bulletin of experimental biology and medicine200612 citationsPMID: 17603664

Plain Language Summary

This animal study demonstrated neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex. The peptide reduced brain damage and preserved memory function after cortical ischemia, supporting its therapeutic potential for stroke treatment.

Abstract

Semax had a pronounced neuroprotective and antiamnesic effect during focal photoinduced ischemia of the prefrontal cortex. Intranasal administration of Semax for 6 days decreased the volume of cortical infarction and improved retention and performance of conditioned passive avoidance response.

Authors

Romanova, G A; Silachev, D N; Shakova, F M; Kvashennikova, Yu N; Viktorov, I V; Shram, S I; Myasoedov, N F