Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging.

Bulletin of experimental biology and medicine2006PMID: 17426848

Randomized Controlled TrialEpitalon

Plain Language Summary

In a 12-year randomized clinical study of elderly patients with coronary disease and accelerated cardiovascular aging, Epithalamin reduced functional age and cardiovascular aging while improving exercise tolerance. Mortality was 28% lower in the Epithalamin group, with cardiovascular mortality and incidence of cardiovascular failure and respiratory diseases both reduced 2-fold compared to controls.

Abstract

A 12-year randomized clinical study of epithalamine (pineal gland peptide preparation) was carried out in elderly patients with coronary disease and accelerated aging of the cardiovascular system. Long-term treatment with epithalamine decreased the functional age and degree of cardiovascular aging; exercise tolerance increased. After 12 years the number of elderly subjects dead in the group treated by epithalamine was 28% lower than in the control group, despite the same basic therapy. Cardiovascular mortality was 2-fold lower in patients treated by epithalamine; the incidence of cardiovascular failure and respiratory diseases was 2-fold lower in this group. Long-term treatment with epithalamine was associated with a geroprotective effect on the long-term life prognosis in elderly subjects with accelerated aging.

Authors

Korkushko, O V; Khavinson, V Kh; Shatilo, V B; Antonyuk-Shcheglova, I A