[Influence of light regimens, melatonin, and epitalon on amylase activity in the pancreas and small intestine in rats of different age].

Advances in gerontology = Uspekhi gerontologii2006PMID: 17152723

Animal StudyEpitalon

Plain Language Summary

Researchers examined how light conditions and pineal gland substances affect digestive enzyme activity across different ages in rats. The effects of melatonin and Epitalon on pancreatic and intestinal amylase activity varied depending on the type of lighting, the animal's age, and which preparation was used, highlighting the complex interplay between circadian rhythms and digestion.

Abstract

The study shows that keeping rats in different light modes has a different impact on pancreatic and intestine amylase activity and has its peculiarities in regard of age as well as geroprotectors' influence on it. Melatonin use entails pancreatic amylase activity increase in mature animals in natural light of the North-West of Russia (NL) and 24-hour constant light (LD) and on the contrary amylase activity drops in case of using epitalon. Simultaneously, the enzyme activity in young and old rats under LD, melatonin and epitalon decreases. Intestine amylase activity influenced by both preparations rises in NL and drops in LD mode with respect to the control group.

Authors

Svechkina, E B; Tiutiunnik, N N; Vinogradova, I A